Increased coagulation and fibrinolytic potential of solvent-detergent plasma: a comparative study between Omniplasma and fresh frozen plasma.

Autor: van Beers JJ; Central Diagnostic Laboratory, Cluster for Hemostasis and Transfusion, Maastricht University Medical Center, Maastricht, the Netherlands., van Egmond LT; Central Diagnostic Laboratory, Cluster for Hemostasis and Transfusion, Maastricht University Medical Center, Maastricht, the Netherlands., Wetzels RJ; Central Diagnostic Laboratory, Cluster for Hemostasis and Transfusion, Maastricht University Medical Center, Maastricht, the Netherlands., Verhezen PW; Central Diagnostic Laboratory, Cluster for Hemostasis and Transfusion, Maastricht University Medical Center, Maastricht, the Netherlands., Beckers EA; Department of Internal Medicine, Subdivision Hematology, Maastricht University Medical Center, Maastricht, the Netherlands., van Oerle R; Central Diagnostic Laboratory, Cluster for Hemostasis and Transfusion, Maastricht University Medical Center, Maastricht, the Netherlands.; Laboratory for Clinical Thrombosis and Haemostasis, Department of Internal Medicine, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, the Netherlands., Spronk HM; Laboratory for Clinical Thrombosis and Haemostasis, Department of Internal Medicine, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, the Netherlands., Straat RJ; Central Diagnostic Laboratory, Cluster for Hemostasis and Transfusion, Maastricht University Medical Center, Maastricht, the Netherlands., Henskens YM; Central Diagnostic Laboratory, Cluster for Hemostasis and Transfusion, Maastricht University Medical Center, Maastricht, the Netherlands.
Jazyk: angličtina
Zdroj: Vox sanguinis [Vox Sang] 2016 Jul; Vol. 111 (1), pp. 33-42. Date of Electronic Publication: 2016 Feb 29.
DOI: 10.1111/vox.12395
Abstrakt: Background and Objectives: In this study, differences in levels of proteins involved in coagulation and fibrinolysis were compared between fresh frozen (quarantine plasma) and Omniplasma. Furthermore, thawing conditions and plasma stability after thawing were studied.
Materials and Methods: 10 Omniplasma and 10 quarantine plasma units were used to study different procoagulation, anticoagulation and fibrinolytic parameters. Analysis took place at different time-points during plasma storage at 2-6°C.
Results: At baseline, significant reduced levels of factor V, free protein S, α2-antiplasmin and tPA-induced ROTEM lysis time were observed in Omniplasma as compared to quarantine plasma. Moreover, thrombin generation, IXa-AT complex levels and factor XIa were significantly increased in Omniplasma. The majority of the parameters studied remained stable in Omniplasma 48 h after thawing, with the exception of factor VIII (decrease) and IXa-AT (increase).
Conclusion: Our results suggest an increased coagulation potential, presumingly as a result of contact activation during the production process and also, an increased fibrinolytic potential in Omniplasma. The stability of Omniplasma, based upon the different parameters studied, is comparable to Q-plasma. A maximum post-thawing time of 48 hfor Omniplasma can be suggested.
(© 2016 International Society of Blood Transfusion.)
Databáze: MEDLINE
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