Steviol glycosides in purified stevia leaf extract sharing the same metabolic fate.

Autor: Purkayastha S; PureCircle Limited, 915 Harger Road, Suite 250, Oak Brook, IL 60523, USA., Markosyan A; PureCircle Limited, 915 Harger Road, Suite 250, Oak Brook, IL 60523, USA., Prakash I; The Coca-Cola Company, One Coca-Cola Plaza, Atlanta, GA 30126, USA., Bhusari S; The Coca-Cola Company, One Coca-Cola Plaza, Atlanta, GA 30126, USA., Pugh G Jr; The Coca-Cola Company, One Coca-Cola Plaza, Atlanta, GA 30126, USA., Lynch B; Intertek Scientific & Regulatory Consultancy, 2233 Argentia Rd., Suite 201, Mississauga, ON, L5N 2X7, Canada., Roberts A; Intertek Scientific & Regulatory Consultancy, 2233 Argentia Rd., Suite 201, Mississauga, ON, L5N 2X7, Canada. Electronic address: ashley.roberts@intertek.com.
Jazyk: angličtina
Zdroj: Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2016 Jun; Vol. 77, pp. 125-33. Date of Electronic Publication: 2016 Feb 27.
DOI: 10.1016/j.yrtph.2016.02.015
Abstrakt: The safety of steviol glycosides is based on data available on several individual steviol glycosides and on the terminal absorbed metabolite, steviol. Many more steviol glycosides have been identified, but are not yet included in regulatory assessments. Demonstration that these glycosides share the same metabolic fate would indicate applicability of the same regulatory paradigm. In vitro incubation assays with pooled human fecal homogenates, using rebaudiosides A, B, C, D, E, F and M, as well as steviolbioside and dulcoside A, at two concentrations over 24-48 h, were conducted to assess the metabolic fate of various steviol glycoside classes and to demonstrate that likely all steviol glycosides are metabolized to steviol. The data show that glycosidic side chains containing glucose, rhamnose, xylose, fructose and deoxy-glucose, including combinations of α(1-2), β-1, β(1-2), β(1-3), and β(1-6) linkages, were degraded to steviol mostly within 24 h. Given a common metabolite structure and a shared metabolic fate, safety data available for individual steviol glycosides can be used to support safety of purified steviol glycosides in general. Therefore, steviol glycosides specifications adopted by the regulatory authorities should include all steviol glycosides belonging to the five groups of steviol glycosides and a group acceptable daily intake established.
(Copyright © 2016 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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