Depression, anxiety, and antidepressant treatment in women: association with in vitro fertilization outcome.

Autor:	Cesta CE; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. Electronic address: carolyn.cesta@ki.se., Viktorin A; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Olsson H; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Johansson V; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Sjölander A; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Bergh C; Department of Obstetrics and Gynaecology, Institute of Clinical Sciences, Sahlgrenska Academy, Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden., Skalkidou A; Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden., Nygren KG; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Cnattingius S; Clinical Epidemiology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden., Iliadou AN; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Jazyk:	angličtina
Zdroj:	Fertility and sterility [Fertil Steril] 2016 Jun; Vol. 105 (6), pp. 1594-1602.e3. Date of Electronic Publication: 2016 Feb 23.
DOI:	10.1016/j.fertnstert.2016.01.036
Abstrakt:	Objective: To investigate associations between depression, anxiety, and antidepressants before in vitro fertilization (IVF) and IVF cycle outcomes, including pregnancy, live birth, and miscarriage. Design: Nationwide register-based cohort study. Setting: Not applicable. Patient(s): Nulliparous women undergoing their first IVF cycle recorded in the Swedish Quality Register of Assisted Reproduction, January 2007 to December 2012 (n = 23,557). Intervention(s): Not applicable. Main Outcome Measure(s): Associations between diagnoses of depression/anxiety, antidepressants, and IVF cycle outcome evaluated using logistic regression to produce adjusted odds ratios (AOR) and 95% confidence intervals (CI). Result(s): In total, 4.4% of women had been diagnosed with depression/anxiety and/or dispensed antidepressants before their IVF first cycle. The odds for pregnancy and live birth were decreased (n = 1,044; AOR = 0.86; 95% CI, 0.75-0.98; and AOR = 0.83; 95% CI, 0.72-0.96, respectively). For women with a prescription for a selective serotonin reuptake inhibitor (SSRI) only (n = 829), no statistically significant associations were found. Women with non-SSRI antidepressants (n = 52) were at reduced odds of pregnancy (AOR = 0.41; 95% CI, 0.21-0.80) and live birth (AOR = 0.27; 95% CI, 0.11-0.68). Women with a depression/anxiety diagnosis with no antidepressant (n = 164) also had reduced odds of pregnancy (AOR = 0.58; 95% CI, 0.41-0.82) and live birth (AOR = 0.60; 95% CI, 0.41-0.89). Among the women who became pregnant (39.7%), there were no statistically significant associations between exposure and miscarriage except for the women taking non-SSRI antidepressants (AOR = 3.56; 95% CI, 1.06-11.9). Conclusion(s): A diagnosis of depression/anxiety and/or treatment with antidepressants before IVF was associated with slightly reduced odds of pregnancy and live birth. Women with the presence of depression/anxiety without antidepressants had a more pronounced reduction in odds, implying that the underlying disorder is important for the observed association. (Copyright © 2016 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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