Post-transplant lymphoproliferative disorder of the cervical spine mimicking an epidural abscess.

Autor: Wewel JT; Department of Neurosurgery, Rush University Medical Center, 1725 W. Harrison Street, Suite 855, Chicago, IL 60612, USA. Electronic address: Joshua_T_Wewel@rush.edu., Harbhajanka A; Department of Pathology, Rush University Medical Center, Chicago, IL, USA., Kasliwal MK; Department of Neurosurgery, Rush University Medical Center, 1725 W. Harrison Street, Suite 855, Chicago, IL 60612, USA., Ahuja SK; Department of Neurosurgery, Rush University Medical Center, 1725 W. Harrison Street, Suite 855, Chicago, IL 60612, USA., Loew JM; Department of Pathology, Rush University Medical Center, Chicago, IL, USA., Fontes RB; Department of Neurosurgery, Rush University Medical Center, 1725 W. Harrison Street, Suite 855, Chicago, IL 60612, USA.
Jazyk: angličtina
Zdroj: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia [J Clin Neurosci] 2016 Jul; Vol. 29, pp. 175-8. Date of Electronic Publication: 2016 Feb 23.
DOI: 10.1016/j.jocn.2016.01.015
Abstrakt: Post-transplant lymphoproliferative disease (PTLD) is a recognized complication following solid organ and stem cell transplants with subsequent immunosuppression and is the most common malignancy complicating solid organ transplantation. Improved survival and use of aggressive immunosuppression following solid organ transplants have led to increased diagnosis of PTLD. Nevertheless, spinal involvement in PTLD is extremely rare. To our knowledge, this is the first report of PTLD causing epidural spinal cord compression of the cervical spine, mimicking the imaging and pathology of an epidural abscess. The patient underwent posterior and subsequent anterior decompression and stabilization. Rarity of occurrence of PTLD in the spine with absence of diagnostic imaging features may preclude differentiating it from the more commonly occurring lesions such as epidural abscess which occurs in a similar clinical setting. As the management strategy and overall prognosis are dramatically different, the importance of considering PTLD in the differential diagnosis for epidural spinal cord compression in a transplant recipient patient cannot be overemphasized.
(Copyright © 2016 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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