Determinants of quality of life among long-term breast cancer survivors.

Autor:	Chu WO; Breast and Gynaecologic Cancer Registry of Côte d'Or, Centre Georges François Leclerc Comprehensive Cancer Centre, 1 rue Professeur Marion, BP 77980, 21079, Dijon Cedex, France.; EA 4184, Faculty of Medicine, University of Burgundy, Dijon, France., Dialla PO; Breast and Gynaecologic Cancer Registry of Côte d'Or, Centre Georges François Leclerc Comprehensive Cancer Centre, 1 rue Professeur Marion, BP 77980, 21079, Dijon Cedex, France.; EA 4184, Faculty of Medicine, University of Burgundy, Dijon, France., Roignot P; Pathology Centre, 33 rue Nicolas Bornier, 21000, Dijon, France., Bone-Lepinoy MC; Centre Radiotherapie du Parc, 18 cours du General de Gaulle, 21000, Dijon Cedex, France., Poillot ML; Breast and Gynaecologic Cancer Registry of Côte d'Or, Centre Georges François Leclerc Comprehensive Cancer Centre, 1 rue Professeur Marion, BP 77980, 21079, Dijon Cedex, France.; EA 4184, Faculty of Medicine, University of Burgundy, Dijon, France., Coutant C; Department of Surgical Oncology, Centre Georges François Leclerc Comprehensive Cancer Centre, 1 rue Professeur Marion, BP 77980, 21079, Dijon Cedex, France., Arveux P; Breast and Gynaecologic Cancer Registry of Côte d'Or, Centre Georges François Leclerc Comprehensive Cancer Centre, 1 rue Professeur Marion, BP 77980, 21079, Dijon Cedex, France.; EA 4184, Faculty of Medicine, University of Burgundy, Dijon, France., Dabakuyo-Yonli TS; EA 4184, Faculty of Medicine, University of Burgundy, Dijon, France. sdabakuyo@cgfl.fr.; Biostatistics and Quality of Life Unit, Centre Georges François Leclerc Comprehensive Cancer Centre, 1 rue Professeur Marion, BP 77980, 21079, Dijon Cedex, France. sdabakuyo@cgfl.fr.; National Quality of Life and Cancer Clinical Research Platform, Dijon, France. sdabakuyo@cgfl.fr.
Jazyk:	angličtina
Zdroj:	Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation [Qual Life Res] 2016 Aug; Vol. 25 (8), pp. 1981-90. Date of Electronic Publication: 2016 Feb 25.
DOI:	10.1007/s11136-016-1248-z
Abstrakt:	Purpose: To identify the impact of clinical and socio-economic determinants on quality of life (QoL) among breast cancer (BC) survivors 5 years after diagnosis. Methods: A cross-sectional survey was conducted in women diagnosed in 2007 for primary invasive non-metastatic BC and identified through the Côte d'Or BC registry. QoL was assessed with the Medical Outcomes Study 12-item Short Form Health Survey (SF-12), the European Organization for Research and Treatment of Cancer Quality of Life (EORTC-QLQ-C30) and the breast cancer (EORTC-QLQ-BR23) questionnaires. Social support was assessed with Sarason's social support questionnaire, and deprivation was assessed by the EPICES questionnaire. Clinical variables were collected through the registry database. Determinants of QoL were identified using multivariable mixed model analysis for each SF-12 dimension. A sensitivity analysis was conducted with multiple imputations on missing data. Results: Overall, 188 patients on 319 patients (59 %) invited to participate to the survey completed the questionnaires. Five years after breast cancer diagnosis, the disease stages at diagnosis, as well as the treatment received, were not determinants of QoL. Only the age at diagnosis and comorbidities were found to be determinants of QoL. Conclusions: Five years after BC diagnosis, disease severity and the treatment received did not affect QoL.
Databáze:	MEDLINE
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