| Autor: |
Stoicea N; Department of Anesthesiology, The Ohio State University Wexner Medical Center Columbus, OH, USA., Du A; College of Medicine, The Ohio State University Columbus, OH, USA., Lakis DC; College of Medicine, The Ohio State University Columbus, OH, USA., Tipton C; College of Medicine, The Ohio State University Columbus, OH, USA., Arias-Morales CE; Department of Anesthesiology, The Ohio State University Wexner Medical Center Columbus, OH, USA., Bergese SD; Department of Anesthesiology, The Ohio State University Wexner Medical CenterColumbus, OH, USA; Department of Neurological Surgery, The Ohio State University Wexner Medical CenterColumbus, OH, USA. |
| Jazyk: |
angličtina |
| Zdroj: |
Frontiers in genetics [Front Genet] 2016 Feb 09; Vol. 7, pp. 11. Date of Electronic Publication: 2016 Feb 09 (Print Publication: 2016). |
| DOI: |
10.3389/fgene.2016.00011 |
| Abstrakt: |
MicroRNAs (miRNAs), small nucleotide sequences that control gene transcription, have the potential to serve an expanded function as indicators in the diagnosis and progression of neurological disorders. Studies involving debilitating neurological diseases such as, Alzheimer's disease, multiple sclerosis, traumatic brain injuries, Parkinson's disease and CNS tumors, already provide validation for their clinical diagnostic use. These small nucleotide sequences have several features, making them favorable candidates as biomarkers, including function in multiple tissues, stability in bodily fluids, a role in pathogenesis, and the ability to be detected early in the disease course. Cerebrospinal fluid, with its cell-free environment, collection process that minimizes tissue damage, and direct contact with the brain and spinal cord, is a promising source of miRNA in the diagnosis of many neurological disorders. Despite the advantages of miRNA analysis, current analytic technology is not yet affordable as a clinically viable diagnostic tool and requires standardization. The goal of this review is to explore the prospective use of CSF miRNA as a reliable and affordable biomarker for different neurological disorders. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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