Intra-articular implantation of gentamicin impregnated collagen sponge causes joint inflammation and impaired renal function in dogs.
| Autor: | Hayes G; Dr. Galina Hayes, University of Guelph, Clinical Studies, 50 Stone Rd E, Guelph, Ontario, N1G 2W1, Canada, E-mail: gmh59@cornell.edu., Gibson T, Moens NM, Nykamp S, Wood D, Foster R, Lerer A |
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| Jazyk: | angličtina |
| Zdroj: | Veterinary and comparative orthopaedics and traumatology : V.C.O.T [Vet Comp Orthop Traumatol] 2016; Vol. 29 (2), pp. 159-63. Date of Electronic Publication: 2016 Feb 22. |
| DOI: | 10.3415/VCOT-15-05-0088 |
| Abstrakt: | Objective: Gentamicin impregnated collagen sponge (GICS) can be used to treat intra-articular surgical site infections. High local concentrations of gentamicin can be reached for short periods; however the collagen vehicle may persist for much longer periods. We wished to determine the effect of sponge implantation on joint inflammation and renal function. Methods: Eighteen medium sized mixed breed research dogs of hound type were randomized to two groups; arthroscopic implantation of GICS at gentamicin dose = 6 mg/kg (n = 9) or sham operation (n = 9). Endpoints consisted of joint inflammation measured by synovial fluid cell counts and cytokine concentrations; lameness measured by force plate asymmetry indices; and renal function measured by glomerular filtration rate (GFR) study. The prevalence of lesions associated with aminoglycoside nephrotoxicity was assessed by renal biopsy and transmission electron microscopy. Results: Gentamicin impregnated collagen sponge implantation caused joint inflammation (p <0.01), lameness (p = 0.04), and decreased GFR (p = 0.04). No difference was observed in the prevalence of renal lesions on biopsy between the treatment and control groups (p = 0.49). Clinical Significance: Gentamicin impregnated collagen sponge implantation causes joint inflammation and lameness as well as GFR reductions at the dose assessed. Gentamicin impregnated collagen sponge are not recommended for intra-articular implantation in dogs. |
| Databáze: | MEDLINE |
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