Assessment of Salivary Gland Function Using Salivary Scintigraphy in Pre and Post Radioactive Iodine Therapy in Diagnosed Thyroid Carcinoma Patients.
Autor: | Badam RK; Reader, Department of Oral Medicine & Radiology, Panineeya Mahavidhyalaya College of Dental Sciences , Hyderabad, India ., Suram J; Senior Lecturer, Department of Oral Medicine & Radiology, Shadan Dental College , Hyderabad, India ., Babu DB; Professor and Head of Department, Department of Oral Medicine & Radiology, Panineeya Mahavidhyalaya College of Dental Sciences , Hyderabad, India ., Waghray S; Senior Lecturer, Department of Oral Medicine & Radiology, Panineeya Mahavidhyalaya College of Dental Sciences , Hyderabad, India ., Marshal R; Reader, Department of Oral Medicine & Radiology, Panineeya Mahavidhyalaya College of Dental Sciences , Hyderabad, India ., Bontha SC; Professor, Department of Oral Medicine & Radiology, Panineeya Mahavidhyalaya College of Dental Sciences , Hyderabad, India ., Lavanya R; Senior Lecturer, Department of Oral Medicine & Radiology, Panineeya Mahavidhyalaya College of Dental Sciences , Hyderabad, India ., Kanth S; Reader, Department of Oral & Maxillofacial Pathology, Mamatha Dental College , Khammam, Telangana State, India . |
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Jazyk: | angličtina |
Zdroj: | Journal of clinical and diagnostic research : JCDR [J Clin Diagn Res] 2016 Jan; Vol. 10 (1), pp. ZC60-2. Date of Electronic Publication: 2016 Jan 01. |
DOI: | 10.7860/JCDR/2016/16091.7121 |
Abstrakt: | Introduction: Thyroid carcinoma represents less than 1% of all cancers. The first line of treatment for thyroid cancer is partial/total thyroidectomy. High-dose Iodine(131) therapy using Iodine radioisotopes is commonly used in patients with well differentiated thyroid carcinoma after total thyroidectomy. In this process, the non-thyroidal tissues, such as, salivary gland, stomach and breast tissues also take up radioactive iodine. Salivary gland scintigraphy is widely accepted as a sensitive and valid method for evaluation of salivary gland dysfunction after Radioactive Iodine(131) Therapy (RIT). Aim: To assess and compare the salivary flow rates, relative uptake and ejection fractions in parotid and submandibular glands just before and one month after Iodine(131) therapy. Materials and Methods: The study was conducted on 24 patients diagnosed with well differentiated thyroid carcinoma who underwent partial/total thyroidectomy and were due for radioactive iodine therapy. These patients were divided into two groups based on the lesion based dosimetry (Group A: 60-100Gy; Group B: 100-150Gy). Salivary gland assessment was done by salivary gland scintigraphy before and after RIT. Statistical Analysis: The data collected was tabulated and statistically analysed using SPSS software version16 using paired t-test and individual sample t-test. Results: A statistically significant difference in the uptake percent and ejection fraction percent in the parotid and submandibular glands before RIT and one month after RIT was observed in the study. Conclusion: We inferred from the study that there was an overall decrease in uptake percent and ejection fraction percent one month post RIT in both parotid and submandibular glands. Also, a statistically significant difference was noted in the uptake and ejection fraction percent between Group A and Group B concluding the fact that the damage is dose related. |
Databáze: | MEDLINE |
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