Inverse relationship between high-density lipoprotein cholesterol raising and high-sensitivity C-reactive protein reduction in older patients treated with lipid-lowering therapy.

Autor: Brown WV; Emory University School of Medicine, Atlanta, GA, USA. Electronic address: wbrow925@bellsouth.net., Foody JM; Brigham and Women's Hospital, Boston, MA, USA., Zieve FJ; McGuire VA Medical Center, Richmond, VA, USA., Tomassini JE; Merck & Co., Inc., Kenilworth, NJ, USA., Shah A; Merck & Co., Inc., Kenilworth, NJ, USA., Tershakovec AM; Merck & Co., Inc., Kenilworth, NJ, USA.
Jazyk: angličtina
Zdroj: Journal of clinical lipidology [J Clin Lipidol] 2016 Jan-Feb; Vol. 10 (1), pp. 116-23. Date of Electronic Publication: 2015 Oct 13.
DOI: 10.1016/j.jacl.2015.10.002
Abstrakt: Background: Little is known regarding relationships between high-sensitivity C-reactive protein (hsCRP) and lipoproteins other than low-density lipoprotein cholesterol (LDL-C). High-density lipoprotein (HDL), with both anti-inflammatory and cholesterol-mediating effects, is of particular interest. This exploratory analysis assessed associations between hsCRP and lipids in older (>65 years) patients with moderate and/or high cardiovascular disease risk, before and after treatment with ezetimibe/simvastatin (E/S) or atorvastatin (ATV).
Methods: An analysis of a multicenter, randomized, double-blind, 12-week study. Correlations were assessed in 1054 patients with both baseline and 12-week hsCRP ≤ 10 mg/L, pooled across doses of E/S (10/20 and 10/40 mg) and ATV (10, 20, and 40 mg), and combined E/S + ATV treatments. Because of multiple comparisons, observed relationships were considered significant only if P values were < .01.
Results: Correlations between baseline levels of hsCRP and either LDL-C, non-HDL-C, or apolipoprotein B were weak and nonsignificant in the E/S, ATV, and E/S + ATV groups. After 12 weeks of treatment, these correlations increased slightly and significantly in all groups, except for LDL-C in the ATV group. HDL-C was significantly but inversely correlated with hsCRP in the ATV and E/S + ATV groups at baseline, and in all groups at 12 weeks. Only with HDL-C did change correlate with change in hsCRP in both the E/S and combined groups.
Conclusions: Relationships between hsCRP and lipid factors in older patients were weak at baseline and somewhat stronger after treatment. HDL-C was inversely and consistently correlated with baseline and 12-week on-treatment hsCRP and with therapy-induced changes in HDL-C and hsCRP.
(Copyright © 2016 National Lipid Association. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: