Cerebral Cortical Circuitry Formation Requires Functional Glycine Receptors.

Autor:	Morelli G; BIOMED Research Institute, Hasselt University, Hasselt 3500, Belgium.; GIGA-Neurosciences.; Interdisciplinary Cluster for Applied Genoproteomics (GIGA-R)., Avila A; Program in Neurosciences and Mental Health, SickKids Research Institute, The Hospital for Sick Children (SickKids), Toronto, ON, CanadaM5G 1X8., Ravanidis S; BIOMED Research Institute, Hasselt University, Hasselt 3500, Belgium., Aourz N; Department of Pharmaceutical Chemistry and Drug Analysis, C4N, Center for Neuroscience, Vrije Universiteit Brussel, 1090 Brussel, Belgium., Neve RL; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Smolders I; Department of Pharmaceutical Chemistry and Drug Analysis, C4N, Center for Neuroscience, Vrije Universiteit Brussel, 1090 Brussel, Belgium., Harvey RJ; Department of Pharmacology, UCL School of Pharmacy, London WC1N 1AX, UK., Rigo JM; BIOMED Research Institute, Hasselt University, Hasselt 3500, Belgium., Nguyen L; GIGA-Neurosciences.; Interdisciplinary Cluster for Applied Genoproteomics (GIGA-R).; Walloon Excellence in Lifesciences and Biotechnology (WELBIO), University of Liège, C.H.U. Sart Tilman, Liège 4000, Belgium., Brône B; BIOMED Research Institute, Hasselt University, Hasselt 3500, Belgium.
Jazyk:	angličtina
Zdroj:	Cerebral cortex (New York, N.Y. : 1991) [Cereb Cortex] 2017 Mar 01; Vol. 27 (3), pp. 1863-1877.
DOI:	10.1093/cercor/bhw025
Abstrakt:	The development of the cerebral cortex is a complex process that requires the generation, migration, and differentiation of neurons. Interfering with any of these steps can impair the establishment of connectivity and, hence, function of the adult brain. Neurotransmitter receptors have emerged as critical players to regulate these biological steps during brain maturation. Among them, α2 subunit-containing glycine receptors (GlyRs) regulate cortical neurogenesis and the present work demonstrates the long-term consequences of their genetic disruption on neuronal connectivity in the postnatal cerebral cortex. Our data indicate that somatosensory cortical neurons of Glra2 knockout mice (Glra2KO) have more dendritic branches with an overall increase in total spine number. These morphological defects correlate with a disruption of the excitation/inhibition balance, thereby increasing network excitability and enhancing susceptibility to epileptic seizures after pentylenetetrazol tail infusion. Taken together, our findings show that the loss of embryonic GlyRα2 ultimately impairs the formation of cortical circuits in the mature brain. (© The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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