Malignant Peripheral Nerve Sheath Tumor With Osseous Heterologous Differentiation in Uncommon Locations (Heart and Retropharynx).

Autor:	Machado I; Instituto Valenciano de Oncología, Valencia, Spain isidro.machado@uv.es., Arana E; Instituto Valenciano de Oncología, Valencia, Spain., Cruz J; Instituto Valenciano de Oncología, Valencia, Spain., Brotons S; Instituto Valenciano de Oncología, Valencia, Spain., Vendrell J; Instituto Valenciano de Oncología, Valencia, Spain., Escriba I; Instituto Valenciano de Oncología, Valencia, Spain., Chust ML; Instituto Valenciano de Oncología, Valencia, Spain., Martínez-Banaclocha N; Hospital General de Alicante, Alicante, Spain., Lavernia J; Instituto Valenciano de Oncología, Valencia, Spain., Llombart-Bosch A; University of Valencia, Valencia, Spain.
Jazyk:	angličtina
Zdroj:	International journal of surgical pathology [Int J Surg Pathol] 2016 Aug; Vol. 24 (5), pp. 456-62. Date of Electronic Publication: 2016 Feb 16.
DOI:	10.1177/1066896916632908
Abstrakt:	We report two cases of malignant peripheral nerve sheath tumor (MPNST) in an uncommon location (heart and retropharynx) both with divergent osseous heterologous differentiation. We present the pathological and immunohistochemical studies that confirmed the neurogenic origin. The histopathology of the tumor arising in the retropharynx showed a transition from a neurofibroma to MPNST, making this a new report of an MPNST arising from a plexiform neurofibroma without neurofibromatosis. Primary cardiac MPNST with osseous differentiation has never been reported before. In conclusion, the histology of MPNSTs is very heterogeneous, showing no specific diagnostic immunoprofile or genetic alteration. Thus, it is important to rule out other histologically similar tumors, particularly in cases arising in uncommon locations or tumors with divergent heterologous differentiation. (© The Author(s) 2016.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu