Is galectin-3 associated with urinary albumin excretion in type 2 diabetes?
| Autor: | Yücel N; Dr. Lütfi Kırdar Kartal EAH, Biochemistry Department, Turkey. yucel.nihal@yahoo.com., Çakır Madenci Ö, Bölük A, Köroğlu Dağdelen L, Temel Y, Sargın M, Orçun A |
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| Jazyk: | angličtina |
| Zdroj: | Endokrynologia Polska [Endokrynol Pol] 2016; Vol. 67 (6), pp. 580-584. Date of Electronic Publication: 2016 Feb 17. |
| DOI: | 10.5603/EP.a2016.0036 |
| Abstrakt: | Introduction: The relationship between galectin-3 and diabetes mellitus or renal function has recently been investigated. In this study, we tried to evaluate the association of galectin-3 in urinary albumin excretion levels in type 2 diabetic patients. Material and Methods: In a group of 137 type 2 diabetes patients, the mean of the last three urinary microalbumin/creatinine ratios and galectin-3 levels were evaluated. The patient group was divided into three subgroups according to their level of albuminuria calculated with urine microalbumin/creatinine ratio. Results: There was no significant difference between the galectin values of the three subgroups. Significant differences were observed between GFR results of group 1 vs. 3 (p < 0.0001) and group 2 vs. 3 (p = 0.0006), and serum creatinine results of group 1 vs. 3 (p = 0.0003) and group 2 vs. 3 (p < 0.0001). The three subgroups did not reveal any significant difference concerning the age, BMI, duration of DM, FPG, and HbA1c levels. Conclusions: We concluded that serum galectin-3 values are not affected by the levels of urinary albumin excretion in DM patients. We could not find any relation between galectin-3 and the parameters of DM such as FPG, HbA1c, and duration of the disease. (Endokrynol Pol 2016; 67 (6): 580-584). |
| Databáze: | MEDLINE |
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