Renal Tumors in 26-Week Tg.Rash2 Mice Carcinogenicity Studies.

Autor:	Paranjpe MG; BioReliance by SAFC, Rockville, Maryland, USA madhav.paranjpe@bioreliance.com., Belich JL; BioReliance by SAFC, Rockville, Maryland, USA., McKeon ME; BioReliance by SAFC, Rockville, Maryland, USA., Elbekai RH; Parexel, International, Bethesda, Maryland, USA., Mann PC; EPL NorthWest, Seattle, Washington, USA., Hard GC; Private Consultant, Tairua, New Zealand., Seely JC; EPL North Carolina, Research Triangle Park, North Carolina, USA.
Jazyk:	angličtina
Zdroj:	Toxicologic pathology [Toxicol Pathol] 2016 Jul; Vol. 44 (5), pp. 633-5. Date of Electronic Publication: 2016 Feb 16.
DOI:	10.1177/0192623315627216
Abstrakt:	We report renal tubular adenomas and a carcinoma in 26-week Tg.rasH2 mouse carcinogenicity studies, which have not been reported to date either at our facility or in other published data. However, during the year 2014, renal tubular tumors were present in 4 studies conducted at our facility. Because of their morphological similarity to the amphophilic-vacuolar (AV) phenotypic variant of renal tubule tumors noted in Sprague-Dawley and Fischer 344 rats, which are thought to be familial, as well as the genetic homogeneity of Tg.rasH2 mice, we tracked the parents of these mice with tumors in each study. The origin of these tumors could not be traced back to any of the parents or even an animal barrier, and these tumors were not attributed to the vehicle or test article. Although the exact mechanism of tumorigenesis was not known, based on the available information, the development of renal tumors in these mice was considered random and spontaneous. (© The Author(s) 2016.)
Databáze:	MEDLINE
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