Control of Trachoma from Achham District, Nepal: A Cross-Sectional Study from the Nepal National Trachoma Program.

Autor: Pant BP; Geta Eye Hospital, Dhangadhi, Nepal., Bhatta RC; Geta Eye Hospital, Dhangadhi, Nepal., Chaudhary JS; Geta Eye Hospital, Dhangadhi, Nepal., Awasthi S; Geta Eye Hospital, Dhangadhi, Nepal., Mishra S; Nepal Netra Jyoti Sangh, Tripureswor, Kathmandu, Nepal., Sharma S; Nepal Netra Jyoti Sangh, Tripureswor, Kathmandu, Nepal., Cuddapah PA; F.I. Proctor Foundation, University of California, San Francisco, San Francisco, California, United States of America., Gwyn SE; Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America., Stoller NE; F.I. Proctor Foundation, University of California, San Francisco, San Francisco, California, United States of America., Martin DL; Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America., Keenan JD; F.I. Proctor Foundation, University of California, San Francisco, San Francisco, California, United States of America.; Department of Ophthalmology, University of California, San Francisco, San Francisco, California, United States of America., Lietman TM; F.I. Proctor Foundation, University of California, San Francisco, San Francisco, California, United States of America.; Department of Ophthalmology, University of California, San Francisco, San Francisco, California, United States of America.; Department of Epidemiology & Biostatistics, University of California, San Francisco, San Francisco, California, United States of America., Gaynor BD; F.I. Proctor Foundation, University of California, San Francisco, San Francisco, California, United States of America.; Department of Ophthalmology, University of California, San Francisco, San Francisco, California, United States of America.
Jazyk: angličtina
Zdroj: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2016 Feb 12; Vol. 10 (2), pp. e0004462. Date of Electronic Publication: 2016 Feb 12 (Print Publication: 2016).
DOI: 10.1371/journal.pntd.0004462
Abstrakt: Background: The WHO seeks to control trachoma as a public health problem in endemic areas. Achham District in western Nepal was found to have TF (trachoma follicular) above 20% in a 2006 government survey, triggering 3 annual mass drug administrations finishing in 2010. Here we assess the level of control that has been achieved using surveillance for clinical disease, ocular chlamydia trachomatis infection, and serology for antibodies against chlamydia trachomatis protein antigens.
Methods: We conducted a cross-sectional survey of children aged 1-9 years in communities in Achham District in early 2014 including clinical examination validated with photographs, conjunctival samples for Chlamydia trachomatis (Amplicor PCR), and serological testing for antibodies against chlamydia trachomatis protein antigens pgp3 and CT694 using the Luminex platform.
Findings: In 24 randomly selected communities, the prevalence of trachoma (TF and/or TI) in 1-9 year olds was 3/1124 (0.3%, 95% CI 0.1 to 0.8%), and the prevalence of ocular chlamydia trachomatis infection was 0/1124 (0%, 95% CI 0 to 0.3%). In 18 communities selected because they had the highest prevalence of trachoma in a previous survey, the prevalence of TF and/or TI was 7/716 (1.0%, 95% CI 0.4 to 2.0%) and the prevalence of ocular chlamydia trachomatis infection was 0/716 (0%, 95% CI 0 to 0.5%). In 3 communities selected for serological testing, the prevalence of trachoma was 0/68 (0%, 95% CI 0 to 5.3%), the prevalence of ocular chlamydia trachomatis infection was 0/68 (0%, 95% CI 0 to 0.5%), the prevalence of antibodies against chlamydia trachomatis protein antigen pgp3 was 1/68 (1.5%, 95% CI 0.04% to 7.9%), and the prevalence of antibodies against chlamydia trachomatis protein antigen CT694 was 0/68 (0%, 95% CI 0 to 5.3%).
Conclusion/significance: This previously highly endemic district in Nepal has little evidence of recent clinical disease, chlamydia trachomatis infection, or serological evidence of trachoma, suggesting that epidemiological control has been achieved.
Databáze: MEDLINE
Externí odkaz: