Carotid Plaque Characterization, Stenosis, and Intima-Media Thickness According to Age and Gender in a Large Registry Cohort.

Autor: Boulos NM; Division of Cardiology, Department of Medicine, University of California, Irvine, California., Gardin JM; Department of Medicine, Hackensack University Medical Center, Hackensack, New Jersey., Malik S; Division of Cardiology, Department of Medicine, University of California, Irvine, California., Postley J; Department of Medicine, Columbia University, New York, New York., Wong ND; Division of Cardiology, Department of Medicine, University of California, Irvine, California. Electronic address: ndwong@uci.edu.
Jazyk: angličtina
Zdroj: The American journal of cardiology [Am J Cardiol] 2016 Apr 01; Vol. 117 (7), pp. 1185-91. Date of Electronic Publication: 2016 Jan 21.
DOI: 10.1016/j.amjcard.2015.12.062
Abstrakt: Carotid intima-media thickness (CIMT) is a well-established predictor of cardiovascular disease events. Not well described, however, is the prevalence of plaque and stenosis severity and how this varies according to extent of CIMT, age, and gender. We evaluated the extent of carotid plaque and stenosis severity according to CIMT, age, and gender in a large CIMT screening registry. We studied 9,347 women and 12,676 men (n = 22,023) who received carotid ultrasound scans. The presence and severity of both carotid plaque and stenosis was compared according to extent of CIMT (≥1 mm vs <1 mm), age, and gender using the chi-square test of proportions. Among those aged <45 to ≥80 years, the prevalence of CIMT ≥1 mm ranged from 0.13% to 29.3% in women and 0.6% to 40.1% in men, stenosis ≥50% from 0.1% to 14.9% in women and 0.1% to 13.2% in men, and mixed and/or soft plaque from 7.1% to 66.5% in women, and 9.2% to 65.8% in men (all p <0.001 across age groups). Even when CIMT levels were <1 mm, >30% of patients demonstrated mixed or soft plaque potentially prone to rupture. Of those with CIMT ≥1 mm, more than 70% had such mixed or soft plaque and more than 40% demonstrated stenoses of 30% or greater. In conclusion, we describe in a large CIMT registry study a substantial age-related increase in both men and women of increased CIMT, plaque presence, and severity, and stenosis. Even in those with normal CIMT, mixed or soft plaque was common, further demonstrating the value in assessing for plaque when doing carotid ultrasound.
(Copyright © 2016 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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