Sexual differentiation and reproductive development of female rat offspring after paternal exposure to the anti-tumor pharmaceutical cisplatin.

Autor: E Silva PV; Department of Morphology, Institute of Biosciences of Botucatu, UNESP-Univ Estadual Paulista, Botucatu, SP, Brazil., da Silva RF; Department of Morphology, Institute of Biosciences of Botucatu, UNESP-Univ Estadual Paulista, Botucatu, SP, Brazil., Borges Cdos S; Department of Morphology, Institute of Biosciences of Botucatu, UNESP-Univ Estadual Paulista, Botucatu, SP, Brazil., Cavariani MM; Department of Morphology, Institute of Biosciences of Botucatu, UNESP-Univ Estadual Paulista, Botucatu, SP, Brazil., de Almeida Francia CC; Department of Anatomy, Institute of Biosciences of Botucatu, UNESP-Univ Estadual Paulista, Botucatu, SP, Brazil., Júnior FB; Department of Clinical, Toxicological and Bromatological Analyses, Faculty of Pharmaceutical Sciences of Ribeirão Preto, USP-University of São Paulo, Ribeirão Preto, SP, Brazil., De Grava Kempinas W; Department of Morphology, Institute of Biosciences of Botucatu, UNESP-Univ Estadual Paulista, Botucatu, SP, Brazil. Electronic address: kempinas@ibb.unesp.br.
Jazyk: angličtina
Zdroj: Reproductive toxicology (Elmsford, N.Y.) [Reprod Toxicol] 2016 Apr; Vol. 60, pp. 112-22. Date of Electronic Publication: 2016 Feb 08.
DOI: 10.1016/j.reprotox.2016.02.005
Abstrakt: Cisplatin (CP) is used to treat a number of cancers, including testicular cancer. Studies indicate that CP-treatment can impair spermatogenesis in humans and rodents by germ cell DNA binding, through different modes of action. CP-paternal exposure resulted in adverse effects in F1 male offspring. In this study, F1 female offspring was assessed for reproductive development after CP-paternal exposure. Peri-pubertal male rats, treated with 1mg/Kg/day of CP or vehicle for 3 weeks, were mated with unexposed females. F1 female offspring of CP-treated fathers showed a decrease in fetal ovary germ cells, in estrous cycle length and FSH levels, and an increase in the percentage of antral follicles in adults. Based on our previous results and the findings of the present work we concluded that CP-paternal exposure leads to adverse effects on rat male and female reproductive development, raising concern, in humans, for children born to men exposed to CP.
(Copyright © 2016 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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