Coronary anatomy as related to bicuspid aortic valve morphology.

Autor:	Koenraadt WM; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands., Tokmaji G; Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands., DeRuiter MC; Department of Anatomy & Embryology, Leiden University Medical Center, Leiden, The Netherlands., Vliegen HW; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands., Scholte AJ; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands., Siebelink HM; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands., Gittenberger-de Groot AC; Department of Anatomy & Embryology, Leiden University Medical Center, Leiden, The Netherlands., de Graaf MA; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands., Wolterbeek R; Department of Medical Statistics, Leiden University Medical Center, Leiden, The Netherlands., Mulder BJ; Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands., Bouma BJ; Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands., Schalij MJ; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands., Jongbloed MR; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands Department of Anatomy & Embryology, Leiden University Medical Center, Leiden, The Netherlands.
Jazyk:	angličtina
Zdroj:	Heart (British Cardiac Society) [Heart] 2016 Jun 15; Vol. 102 (12), pp. 943-9. Date of Electronic Publication: 2016 Feb 10.
DOI:	10.1136/heartjnl-2015-308629
Abstrakt:	Objective: Variable coronary anatomy has been described in patients with bicuspid aortic valves (BAVs). This was never specified to BAV morphology, and prognostic relevance of coronary vessel dominance in this patient group is unclear. The purpose of this study was to evaluate valve morphology in relation to coronary artery anatomy and outcome in patients with isolated BAV and with associated aortic coarctation (CoA). Methods: Coronary anatomy was evaluated in 186 patients with BAV (141 men (79%), 51±14 years) by CT and invasive coronary angiography. Correlation of coronary anatomy was made with BAV morphology and coronary events. Results: Strictly bicuspid valves (without raphe) with left-right cusp fusion (type 1B) had more left dominant coronary systems compared with BAVs with left-right cusp fusion with a raphe (type 1A) (48% vs. 26%, p=0.047) and showed more separate ostia (28% vs. 9%, p=0.016). Type 1B BAVs had more coronary artery disease than patients with type 1A BAV (36% vs. 19%, p=0.047). More left dominance was seen in BAV patients with CoA than in patients without (65% vs. 24%, p<0.05). Conclusions: The incidence of a left dominant coronary artery system and separate ostia was significantly related to BAVs with left-right fusion without a raphe (type 1B). These patients more often had significant coronary artery disease. In patients with BAV and CoA, left dominancy is more common. (Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu