Increase in Fracture Risk Following Unintentional Weight Loss in Postmenopausal Women: The Global Longitudinal Study of Osteoporosis in Women.

Autor: Compston JE; Cambridge Biomedical Campus, Cambridge, UK., Wyman A; Center for Outcomes Research, University of Massachusetts Medical School, Worcester, MA, USA., FitzGerald G; Center for Outcomes Research, University of Massachusetts Medical School, Worcester, MA, USA., Adachi JD; St Joseph's Healthcare, McMaster University, Hamilton, Canada., Chapurlat RD; Division of Rheumatology, INSERM U1033, Université de Lyon, Hôpital E Herriot, Lyon, France., Cooper C; MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK., Díez-Pérez A; Hospital del Mar-IMIM-Autonomous University of Barcelona, Barcelona, Spain.; RETICEF, Instituto Carlos III, Madrid, Spain., Gehlbach SH; Center for Outcomes Research, University of Massachusetts Medical School, Worcester, MA, USA., Greenspan SL; University of Pittsburgh, Pittsburgh, PA, USA., Hooven FH; University of Massachusetts Medical School, Worcester, MA, USA., LaCroix AZ; Fred Hutchinson Cancer Research Center, Seattle, WA, USA., March L; University of Sydney Institute of Bone and Joint Research and Department of Rheumatology, Royal North Shore Hospital, Sydney, Australia., Netelenbos JC; Department of Endocrinology, VU University Medical Center, Amsterdam, Netherlands., Nieves JW; Helen Hayes Hospital and Columbia University, West Haverstraw, NY, USA., Pfeilschifter J; Department of Internal Medicine III, Alfried Krupp Krankenhaus, Essen, Germany., Rossini M; Rheumatology Section, Department of Medicine, University of Verona, Verona, Italy., Roux C; Paris Descartes University, Cochin Hospital, Paris, France., Saag KG; Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, USA., Siris ES; Columbia University Medical Center, New York, NY, USA., Silverman S; Department of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Watts NB; Mercy Health Osteoporosis and Bone Health Services, Cincinnati, OH, USA., Anderson FA Jr; Cambridge Biomedical Campus, Cambridge, UK.
Jazyk: angličtina
Zdroj: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research [J Bone Miner Res] 2016 Jul; Vol. 31 (7), pp. 1466-72.
DOI: 10.1002/jbmr.2810
Abstrakt: Increased fracture risk has been associated with weight loss in postmenopausal women, but the time course over which this occurs has not been established. The aim of this study was to examine the effects of unintentional weight loss of ≥10 lb (4.5 kg) in postmenopausal women on fracture risk at multiple sites up to 5 years after weight loss. Using data from the Global Longitudinal Study of Osteoporosis in Women (GLOW), we analyzed the relationships between self-reported unintentional weight loss of ≥10 lb at baseline, year 2, or year 3 and incident clinical fracture in the years after weight loss. Complete data were available in 40,179 women (mean age ± SD 68 ± 8.3 years). Five-year cumulative fracture rate was estimated using the Kaplan-Meier method, and adjusted hazard ratios for weight loss as a time-varying covariate were calculated from Cox multiple regression models. Unintentional weight loss at baseline was associated with a significantly increased risk of fracture of the clavicle, wrist, spine, rib, hip, and pelvis for up to 5 years after weight loss. Adjusted hazard ratios showed a significant association between unintentional weight loss and fracture of the hip, spine, and clavicle within 1 year of weight loss, and these associations were still present at 5 years. These findings demonstrate increased fracture risk at several sites after unintentional weight loss in postmenopausal women. This increase is found as early as 1 year after weight loss, emphasizing the need for prompt fracture risk assessment and appropriate management to reduce fracture risk in this population. © 2016 American Society for Bone and Mineral Research.
(© 2016 American Society for Bone and Mineral Research.)
Databáze: MEDLINE
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