Percutaneous Thermal Ablation of Breast Cancer Metastases in Oligometastatic Patients.

Autor: Barral M; Interventional Radiology Department, Institut Gustave Roussy, 114, rue Edouard Vaillant, 94805, Villejuif, France. matthias_barral@yahoo.fr., Auperin A; Biostatistics and Epidemiology Unit, Institut Gustave Roussy, 114, rue Edouard Vaillant, 94805, Villejuif, France., Hakime A; Interventional Radiology Department, Institut Gustave Roussy, 114, rue Edouard Vaillant, 94805, Villejuif, France., Cartier V; Interventional Radiology Department, Institut Gustave Roussy, 114, rue Edouard Vaillant, 94805, Villejuif, France., Tacher V; Interventional Radiology Department, Institut Gustave Roussy, 114, rue Edouard Vaillant, 94805, Villejuif, France., Otmezguine Y; Radiotherapy, Centre Clinique de la Porte de Saint-Cloud, 37 avenue Victor Hugo, 92100, Boulogne Billancourt, France., Tselikas L; Interventional Radiology Department, Institut Gustave Roussy, 114, rue Edouard Vaillant, 94805, Villejuif, France., de Baere T; Interventional Radiology Department, Institut Gustave Roussy, 114, rue Edouard Vaillant, 94805, Villejuif, France., Deschamps F; Interventional Radiology Department, Institut Gustave Roussy, 114, rue Edouard Vaillant, 94805, Villejuif, France.
Jazyk: angličtina
Zdroj: Cardiovascular and interventional radiology [Cardiovasc Intervent Radiol] 2016 Jun; Vol. 39 (6), pp. 885-93. Date of Electronic Publication: 2016 Feb 09.
DOI: 10.1007/s00270-016-1301-x
Abstrakt: Objective: To evaluate prognostic factors associated with local control and disease-free-survival (DFS) of oligometastatic breast cancer patients treated by percutaneous thermal ablation (PTA).
Materials and Methods: Seventy-nine consecutive patients (54.5 ± 11.2 years old) with 114 breast cancer metastases (28.9 ± 16.1 mm in diameter), involving the lungs, the liver, and/or the bone, were treated using PTA with a curative intent. The goal was to achieve a complete remission in association with systemic chemotherapy and hormonal therapy. We retrospectively evaluated the prognostic factors associated with 1- and 2-year local control and the 1- and 2-year DFS rates.
Results: The 1- and 2-year local control rates were 83.0 and 76.1 %, respectively. Tumor burden was associated with a poorer outcome for local control after PTA (HR 1.027 by additional millimeter, p = 0.026; >4 cm HR 3.90). The 1- and 2-year DFS rates were 54.2 and 30.4 %, respectively. In multivariate analysis, triple-negative histological subtype and increased size of treated metastases were associated with a poorer DFS (HR 2.22; 95 % CI [1.13-4.36]; p = 0.02 and HR 2.43; 95 % CI [1.22-4.82]; p = 0.011, respectively).
Conclusion: PTA is effective for local control of breast cancer oligometastases. Tumor burden >4 cm and triple-negative histological subtype are associated with a poorer outcome.
Databáze: MEDLINE
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