Absence of Tumor-Infiltrating Lymphocyte Is a Reproducible Predictive Factor for Sentinel Lymph Node Metastasis: A Multicenter Database Study by the Brazilian Melanoma Group.

Autor: Duprat JP; AC Camargo Cancer Center, São Paulo, Brazil., Brechtbülh ER; AC Camargo Cancer Center, São Paulo, Brazil., Costa de Sá B; AC Camargo Cancer Center, São Paulo, Brazil., Enokihara M; Medical School, São Paulo Federal University, São Paulo, Brazil., Fregnani JH; Barretos Cancer Hospital, Barretos, Brazil., Landman G; Medical School, São Paulo Federal University, São Paulo, Brazil., Maia M; Santa Casa de Misericórdia, São Paulo, Brazil., Riccardi F; Santa Rita Hospital, Porto Alegre, Brazil., Belfort FA; Sirio Libanês Hospital, Oswaldo Cruz Hospital, São José Hospital, São Paulo, Brazil., Wainstein A; Minas Gerais School of Medicine, Belo Horizonte, Brazil., Moredo LF; AC Camargo Cancer Center, São Paulo, Brazil., Steck H; Mario Gatti Hospital, Campinas, Brazil., Brandão M; AMO Clinic, Salvador, Brazil., Moreno M; Medical School, Community University of Chapecó Region, Chapecó, Brazil., Miranda E; Oncology Department, Pernambuco University, Recife, Brazil., Santos ID; Medical School, São Paulo Federal University, São Paulo, Brazil.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2016 Feb 09; Vol. 11 (2), pp. e0148160. Date of Electronic Publication: 2016 Feb 09 (Print Publication: 2016).
DOI: 10.1371/journal.pone.0148160
Abstrakt: Aims: The aim of this study is to confirm the function of tumor-infiltrating lymphocytes (TILs) in sentinel lymph node (SLN) metastasis.
Materials and Methods: This retrospective study included 633 patients with invasive melanoma who underwent sentinel lymph node biopsy in 7 referral centers certified by the Brazilian Melanoma Group. Independent risk factors of sentinel node metastasis (SNL) were identified by multiple logistic regression.
Results: SLN metastasis was detected in 101 of 633 cases (16.1%) and in 93 of 428 patients (21.7%) when melanomas ≤ 1mm were excluded. By multiple logistic regression, the absence of TILs was as an independent risk factor of SLN metastasis (OR = 1.8; 95%CI: 1.1-3.0), in addition to Breslow index (greater than 2.00 mm), lymph vascular invasion, and presence of mitosis.
Conclusion: SLNB can identify patients who might benefit from immunotherapy, and the determination of predictors of SLNB positivity can help select the proper population for this type of therapy. The absence of TILs is a reproducible parameter that can predict SLNB positivity in melanoma patients, since this study was made with several centers with different dermatopathologists.
Databáze: MEDLINE
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