Limited Effect of Dopaminergic Medication on Straight Walking and Turning in Early-to-Moderate Parkinson's Disease during Single and Dual Tasking.

Autor:	Elshehabi M; Department of Neurodegeneration, Center for Neurology, Hertie Institute for Clinical and Brain Research, University of Tuebingen, Tuebingen, Germany; German Center for Neurodegenerative Disease (DZNE), Tuebingen, Germany., Maier KS; Department of Neurodegeneration, Center for Neurology, Hertie Institute for Clinical and Brain Research, University of Tuebingen, Tuebingen, Germany; German Center for Neurodegenerative Disease (DZNE), Tuebingen, Germany., Hasmann SE; Department of Neurodegeneration, Center for Neurology, Hertie Institute for Clinical and Brain Research, University of Tuebingen, Tuebingen, Germany; German Center for Neurodegenerative Disease (DZNE), Tuebingen, Germany., Nussbaum S; Department of Neurodegeneration, Center for Neurology, Hertie Institute for Clinical and Brain Research, University of Tuebingen, Tuebingen, Germany; German Center for Neurodegenerative Disease (DZNE), Tuebingen, Germany., Herbst H; Neurozentrum Sophienstrasse , Stuttgart , Germany., Heger T; Department of Neurodegeneration, Center for Neurology, Hertie Institute for Clinical and Brain Research, University of Tuebingen, Tuebingen, Germany; German Center for Neurodegenerative Disease (DZNE), Tuebingen, Germany., Berg D; Department of Neurodegeneration, Center for Neurology, Hertie Institute for Clinical and Brain Research, University of Tuebingen, Tuebingen, Germany; German Center for Neurodegenerative Disease (DZNE), Tuebingen, Germany., Hobert MA; Department of Neurodegeneration, Center for Neurology, Hertie Institute for Clinical and Brain Research, University of Tuebingen, Tuebingen, Germany; German Center for Neurodegenerative Disease (DZNE), Tuebingen, Germany., Maetzler W; Department of Neurodegeneration, Center for Neurology, Hertie Institute for Clinical and Brain Research, University of Tuebingen, Tuebingen, Germany; German Center for Neurodegenerative Disease (DZNE), Tuebingen, Germany.
Jazyk:	angličtina
Zdroj:	Frontiers in aging neuroscience [Front Aging Neurosci] 2016 Jan 27; Vol. 8, pp. 4. Date of Electronic Publication: 2016 Jan 27 (Print Publication: 2016).
DOI:	10.3389/fnagi.2016.00004
Abstrakt:	Background: In Parkinson's disease (PD), the effects of dopaminergic medication on straight walking and turning were mainly investigated under single tasking (ST) conditions. However, multitasking situations are considered more daily relevant. Methods: Thirty-nine early-to-moderate PD patients performed the following standardized ST and dual tasks as fast as possible for 1 min during On- and Off-medication while wearing inertial sensors: straight walking and turning, checking boxes, and subtracting serial 7s. Quantitative gait parameters as well as velocity of the secondary tasks were analyzed. Results: The following parameters improved significantly in On-medication during ST: gait velocity during straight walking (p = 0.03); step duration (p = 0.048) and peak velocity (p = 0.04) during turning; velocity of checking boxes during ST (p = 0.04) and DT (p = 0.04). Velocity of checking boxes was the only parameter that also improved during DT. Conclusion: These results suggest that dopaminergic medication does not relevantly influence straight walking and turning in early-to-moderate PD during DT.
Databáze:	MEDLINE
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