MxA mRNA expression as a biomarker of interferon beta response in multiple sclerosis patients.

Autor: Matas E; Multiple Sclerosis Unit, Department of Neurology, Hospital Universitari de Bellvitge-IDIBELL, Edifici Tècnic-Quirúrgic, Planta 1, mòdul E, Feixa Llarga s/n, L'Hospitalet de Llobregat 08907, Spain. Electronic address: ematas@bellvitgehospital.cat., Bau L; Multiple Sclerosis Unit, Department of Neurology, Hospital Universitari de Bellvitge-IDIBELL, Edifici Tècnic-Quirúrgic, Planta 1, mòdul E, Feixa Llarga s/n, L'Hospitalet de Llobregat 08907, Spain. Electronic address: lbau@bellvitgehospital.cat., Martínez-Iniesta M; Translational Research Laboratory, Institut Català d'Oncologia-IDIBELL, Gran via s/n, L'Hospitalet de Llobregat 08907, Spain. Electronic address: mmi@iconcologia.net., Romero-Pinel L; Multiple Sclerosis Unit, Department of Neurology, Hospital Universitari de Bellvitge-IDIBELL, Edifici Tècnic-Quirúrgic, Planta 1, mòdul E, Feixa Llarga s/n, L'Hospitalet de Llobregat 08907, Spain. Electronic address: luciaromero@bellvitgehospital.cat., Mañé-Martínez MA; Multiple Sclerosis Unit, Department of Neurology, Hospital Universitari de Bellvitge-IDIBELL, Edifici Tècnic-Quirúrgic, Planta 1, mòdul E, Feixa Llarga s/n, L'Hospitalet de Llobregat 08907, Spain; Department of Neurology, Joan XXIII University Hospital, Universitat Rovira i Virgili, Dr. Mallafrè Guasch, 4, Tarragona 43005, Spain. Electronic address: amane.hj23.ics@gencat.cat., Cobo-Calvo Á; Department of Neurology, Hospital del Mar Medical Research Institute, Dr. Aiguader, 88, Barcelona 08003, Spain. Electronic address: acobo@imim.es., Martínez-Yélamos S; Multiple Sclerosis Unit, Department of Neurology, Hospital Universitari de Bellvitge-IDIBELL, Edifici Tècnic-Quirúrgic, Planta 1, mòdul E, Feixa Llarga s/n, L'Hospitalet de Llobregat 08907, Spain. Electronic address: smartinezy@bellvitgehospital.cat.
Jazyk: angličtina
Zdroj: Journal of neuroimmunology [J Neuroimmunol] 2016 Feb 15; Vol. 291, pp. 73-7. Date of Electronic Publication: 2015 Dec 30.
DOI: 10.1016/j.jneuroim.2015.12.015
Abstrakt: Myxovirus resistance protein A (MxA) is a molecule induced after interferon-β injection. The aim of this study was to investigate whether MxA determination one year after starting interferon-β can predict treatment response in multiple sclerosis patients. MxA mRNA expression was evaluated in blood samples obtained at baseline and at month 12. Clinical variables were prospectively recorded. A threshold of 5 was defined to establish MxA induction. On survival analysis, time to the next relapse and to EDSS progression were significantly longer in patients showing MxA induction, suggesting that MxA induction after one year may be useful to identify interferon-β responders.
(Copyright © 2016 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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