pH-dependent cytotoxic effects of extracts of the marine sponge Polymastia janeirensis on cancer cell lines.

Autor: Biegelmeyer R; a Pharmacognosy Laboratory, Faculty of Pharmacy , Federal University of Rio Grande do Sul (UFRGS) , Porto Alegre , Brazil., Schröder R; b Biochemistry Department, Study Center of Oxidative Stress , Federal University of Rio Grande do Sul (UFRGS) , Porto Alegre , Brazil., Rambo DF; a Pharmacognosy Laboratory, Faculty of Pharmacy , Federal University of Rio Grande do Sul (UFRGS) , Porto Alegre , Brazil., Dresch RR; a Pharmacognosy Laboratory, Faculty of Pharmacy , Federal University of Rio Grande do Sul (UFRGS) , Porto Alegre , Brazil., Carraro JLF; c Department of Invertebrates, National Museum , Federal University of Rio de Janeiro (UFRJ) , Rio de Janeiro , Brazil., Mothes B B; d Zoobotanical Foundation , Museum of Natural Sciences , Porto Alegre , Brazil., Moreira JCF; b Biochemistry Department, Study Center of Oxidative Stress , Federal University of Rio Grande do Sul (UFRGS) , Porto Alegre , Brazil., da Frota Junior MLC; b Biochemistry Department, Study Center of Oxidative Stress , Federal University of Rio Grande do Sul (UFRGS) , Porto Alegre , Brazil., Henriques AT; a Pharmacognosy Laboratory, Faculty of Pharmacy , Federal University of Rio Grande do Sul (UFRGS) , Porto Alegre , Brazil.
Jazyk: angličtina
Zdroj: Natural product research [Nat Prod Res] 2016 Dec; Vol. 30 (23), pp. 2734-2737. Date of Electronic Publication: 2016 Feb 09.
DOI: 10.1080/14786419.2016.1143824
Abstrakt: The purpose of this work was to study the cytotoxic effects of marine sponge Polymastia janeirensis, which has been observed in the field to release an orange substance that is toxic to fish. The result showed that aqueous extract (pH 7.0) was highly cytotoxic to glioma (U87) and neuroblastoma (SHSY5Y) cancer cell lines (IC 50  < 1.0 μg/mL). In addition, this extract showed potent antioxidant and procoagulant (decreased the clotting time by 1.7-fold) activities. Interestingly, the cytotoxic effects were pH-dependent since the viability of the cancer cells was not affected with the extract (pH 5.5). The close similarity between the aqueous extract (pH 7.0) and the orange liquid that is released by the sponge indicates that this potential chemical defence of P. janeirensis deserves further investigation.
Databáze: MEDLINE
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