Grey matter brain injuries are common in Ugandan children with cerebral palsy suggesting a perinatal aetiology in full-term infants.

Autor: Kakooza-Mwesige A; Department of Paediatrics & Child Health, Makerere University College of Health Sciences, Kampala, Uganda.; Astrid Lindgren Children's Hospital, Department of Women's & Children's Health, Neuropediatric Research Unit, Karolinska Institutet, Stockholm, Sweden., Byanyima RK; Mulago Hospital Department of Radiology/Makerere University College of Health Sciences, Kampala, Uganda., Tumwine JK; Department of Paediatrics & Child Health, Makerere University College of Health Sciences, Kampala, Uganda., Eliasson AC; Astrid Lindgren Children's Hospital, Department of Women's & Children's Health, Neuropediatric Research Unit, Karolinska Institutet, Stockholm, Sweden., Forssberg H; Astrid Lindgren Children's Hospital, Department of Women's & Children's Health, Neuropediatric Research Unit, Karolinska Institutet, Stockholm, Sweden., Flodmark O; Department of Clinical Neuroscience, Karolinska Institutet and Department of Neuroradiology, Karolinska University Hospital, Stockholm, Sweden.
Jazyk: angličtina
Zdroj: Acta paediatrica (Oslo, Norway : 1992) [Acta Paediatr] 2016 Jun; Vol. 105 (6), pp. 655-64. Date of Electronic Publication: 2016 Mar 06.
DOI: 10.1111/apa.13352
Abstrakt: Aim: There is limited literature on brain imaging studies of children with cerebral palsy (CP) in low and middle income countries. We investigated neuroimaging patterns of children with CP attending a tertiary referral centre in Uganda to determine how they differed from studies reported from high income countries and their relationship with prenatal and postnatal factors.
Methods: Precontrast and postcontrast computed tomography (CT) scans of 78 CP children aged 2-12 years were conducted using a Philips MX 16-slice CT scanner. Two radiologists, blinded to the patient's clinical status, independently reviewed the scans.
Results: Abnormal CT scans were detected in 69% of the children sampled, with very few having primary white matter injuries (4%). Primary grey matter injuries (PGMI) (44%) and normal scans (31%) were most frequent. Children with a history of hospital admission following birth were three times more likely to have PGMI (odds ratio [OR] 2.8; 95% CI 1.1-7.1), suggesting a perinatal period with medical complications.
Conclusion: Brain imaging patterns in this group of CP children differed markedly from imaging studies reported from high income countries, suggesting a perinatal aetiology in full-term infants and reduced survival in preterm infants.
(©2016 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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