Decreased Fronto-Limbic Activation and Disrupted Semantic-Cued List Learning in Major Depressive Disorder.

Autor:	Kassel MT; 1University of Illinois at Chicago,Department of Psychiatry,Chicago,Illinois., Rao JA; 1University of Illinois at Chicago,Department of Psychiatry,Chicago,Illinois., Walker SJ; 2University of Michigan Medical Center,Department of Psychiatry,Ann Arbor,Michigan., Briceño EM; 2University of Michigan Medical Center,Department of Psychiatry,Ann Arbor,Michigan., Gabriel LB; 1University of Illinois at Chicago,Department of Psychiatry,Chicago,Illinois., Weldon AL; 1University of Illinois at Chicago,Department of Psychiatry,Chicago,Illinois., Avery ET; 2University of Michigan Medical Center,Department of Psychiatry,Ann Arbor,Michigan., Haase BD; 2University of Michigan Medical Center,Department of Psychiatry,Ann Arbor,Michigan., Peciña M; 2University of Michigan Medical Center,Department of Psychiatry,Ann Arbor,Michigan., Considine CM; 2University of Michigan Medical Center,Department of Psychiatry,Ann Arbor,Michigan., Noll DC; 2University of Michigan Medical Center,Department of Psychiatry,Ann Arbor,Michigan., Bieliauskas LA; 2University of Michigan Medical Center,Department of Psychiatry,Ann Arbor,Michigan., Starkman MN; 2University of Michigan Medical Center,Department of Psychiatry,Ann Arbor,Michigan., Zubieta JK; 2University of Michigan Medical Center,Department of Psychiatry,Ann Arbor,Michigan., Welsh RC; 2University of Michigan Medical Center,Department of Psychiatry,Ann Arbor,Michigan., Giordani B; 2University of Michigan Medical Center,Department of Psychiatry,Ann Arbor,Michigan., Weisenbach SL; 1University of Illinois at Chicago,Department of Psychiatry,Chicago,Illinois., Langenecker SA; 2University of Michigan Medical Center,Department of Psychiatry,Ann Arbor,Michigan.
Jazyk:	angličtina
Zdroj:	Journal of the International Neuropsychological Society : JINS [J Int Neuropsychol Soc] 2016 Apr; Vol. 22 (4), pp. 412-25. Date of Electronic Publication: 2016 Feb 02.
DOI:	10.1017/S1355617716000023
Abstrakt:	Objectives: Individuals with major depressive disorder (MDD) demonstrate poorer learning and memory skills relative to never-depressed comparisons (NDC). Previous studies report decreased volume and disrupted function of frontal lobes and hippocampi in MDD during memory challenge. However, it has been difficult to dissociate contributions of short-term memory and executive functioning to memory difficulties from those that might be attributable to long-term memory deficits. Methods: Adult males (MDD, n=19; NDC, n=22) and females (MDD, n=23; NDC, n=19) performed the Semantic List Learning Task (SLLT) during functional magnetic resonance imaging. The SLLT Encoding condition consists of 15 lists, each containing 14 words. After each list, a Distractor condition occurs, followed by cued Silent Rehearsal instructions. Post-scan recall and recognition were collected. Groups were compared using block (Encoding-Silent Rehearsal) and event-related (Words Recalled) models. Results: MDD displayed lower recall relative to NDC. NDC displayed greater activation in several temporal, frontal, and parietal regions, for both Encoding-Silent Rehearsal and the Words Recalled analyses. Groups also differed in activation patterns in regions of the Papez circuit in planned analyses. The majority of activation differences were not related to performance, presence of medications, presence of comorbid anxiety disorder, or decreased gray matter volume in MDD. Conclusions: Adults with MDD exhibit memory difficulties during a task designed to reduce the contribution of individual variability from short-term memory and executive functioning processes, parallel with decreased activation in memory and executive functioning circuits. Ecologically valid long-term memory tasks are imperative for uncovering neural correlates of memory performance deficits in adults with MDD.
Databáze:	MEDLINE
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