The inflammatory markers CRP, IL-6, and IL-10 are associated with cognitive function--data from the Berlin Aging Study II.

Autor: Tegeler C; Research Group on Geriatrics, Charité-Universitätsmedizin Berlin, Berlin, Germany. Electronic address: christina.tegeler@charite.de., O'Sullivan JL; Research Group on Geriatrics, Charité-Universitätsmedizin Berlin, Berlin, Germany., Bucholtz N; Research Group on Geriatrics, Charité-Universitätsmedizin Berlin, Berlin, Germany., Goldeck D; Department of Internal Medicine II, Centre for Medical Research, University of Tübingen, Tübingen, Germany., Pawelec G; Department of Internal Medicine II, Centre for Medical Research, University of Tübingen, Tübingen, Germany., Steinhagen-Thiessen E; Research Group on Geriatrics, Charité-Universitätsmedizin Berlin, Berlin, Germany; Lipid Clinic at the Interdisciplinary Metabolism Center, Charité-Universitätsmedizin Berlin, Berlin, Germany., Demuth I; Research Group on Geriatrics, Charité-Universitätsmedizin Berlin, Berlin, Germany; Institute of Medical and Human Genetics, Charité-Universitätsmedizin Berlin, Berlin, Germany. Electronic address: ilja.demuth@charite.de.
Jazyk: angličtina
Zdroj: Neurobiology of aging [Neurobiol Aging] 2016 Feb; Vol. 38, pp. 112-117. Date of Electronic Publication: 2015 Nov 07.
DOI: 10.1016/j.neurobiolaging.2015.10.039
Abstrakt: Inflammation may be an underlying mechanism in cognitive decline. The present study investigated the relationship between cognitive function and the inflammatory markers C-reactive protein (CRP), interleukin (IL)-6, and IL-10 in a nonclinical sample of elderly adults. Serum levels of CRP, IL-6, and IL-10 were measured in n = 1312 elderly adults (60-85 years, 50.5% females) who underwent comprehensive neuropsychological testing. Multiple linear regression analysis was conducted and adjusted for various demographic and clinical factors. Levels of IL-6, IL-10, and CRP were negatively associated with a composite score of executive function and processing speed, whereas the IL-6 to IL-10 ratio was not predictive for executive function and processing speed. No associations were found between inflammatory markers and verbal episodic memory. These findings suggest a relationship between higher proinflammatory and anti-inflammatory activation of the innate immune system and executive function within the normal range. Further research is needed to examine the relevance of an inflammatory pathway as a potential therapeutic target.
(Copyright © 2016 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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