Toward better public health reporting using existing off the shelf approaches: A comparison of alternative cancer detection approaches using plaintext medical data and non-dictionary based feature selection.

Autor: Kasthurirathne SN; Indiana University School of Informatics and Computing, Indianapolis, IN, USA. Electronic address: snkasthu@iupui.edu., Dixon BE; Regenstrief Institute, Indianapolis, IN, USA; Indiana University Fairbanks School of Public Health, Indianapolis, IN, USA., Gichoya J; Indiana University School of Medicine, Indianapolis, IN, USA., Xu H; Indiana University Fairbanks School of Public Health, Indianapolis, IN, USA., Xia Y; Indiana University School of Medicine, Indianapolis, IN, USA., Mamlin B; Regenstrief Institute, Indianapolis, IN, USA; Indiana University School of Medicine, Indianapolis, IN, USA., Grannis SJ; Regenstrief Institute, Indianapolis, IN, USA; Indiana University School of Medicine, Indianapolis, IN, USA.
Jazyk: angličtina
Zdroj: Journal of biomedical informatics [J Biomed Inform] 2016 Apr; Vol. 60, pp. 145-52. Date of Electronic Publication: 2016 Jan 28.
DOI: 10.1016/j.jbi.2016.01.008
Abstrakt: Objectives: Increased adoption of electronic health records has resulted in increased availability of free text clinical data for secondary use. A variety of approaches to obtain actionable information from unstructured free text data exist. These approaches are resource intensive, inherently complex and rely on structured clinical data and dictionary-based approaches. We sought to evaluate the potential to obtain actionable information from free text pathology reports using routinely available tools and approaches that do not depend on dictionary-based approaches.
Materials and Methods: We obtained pathology reports from a large health information exchange and evaluated the capacity to detect cancer cases from these reports using 3 non-dictionary feature selection approaches, 4 feature subset sizes, and 5 clinical decision models: simple logistic regression, naïve bayes, k-nearest neighbor, random forest, and J48 decision tree. The performance of each decision model was evaluated using sensitivity, specificity, accuracy, positive predictive value, and area under the receiver operating characteristics (ROC) curve.
Results: Decision models parameterized using automated, informed, and manual feature selection approaches yielded similar results. Furthermore, non-dictionary classification approaches identified cancer cases present in free text reports with evaluation measures approaching and exceeding 80-90% for most metrics.
Conclusion: Our methods are feasible and practical approaches for extracting substantial information value from free text medical data, and the results suggest that these methods can perform on par, if not better, than existing dictionary-based approaches. Given that public health agencies are often under-resourced and lack the technical capacity for more complex methodologies, these results represent potentially significant value to the public health field.
(Copyright © 2016 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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