Myocardial Perfusion and Function Are Distinctly Altered by Sevoflurane Anesthesia in Diet-Induced Prediabetic Rats.

Autor: van den Brom CE; Department of Anesthesiology, VU University Medical Center, Boelelaan 1117, 1081 HV Amsterdam, Netherlands; Laboratory for Physiology, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, Netherlands., Boly CA; Department of Anesthesiology, VU University Medical Center, Boelelaan 1117, 1081 HV Amsterdam, Netherlands; Laboratory for Physiology, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, Netherlands., Bulte CS; Department of Anesthesiology, VU University Medical Center, Boelelaan 1117, 1081 HV Amsterdam, Netherlands., van den Akker RF; Department of Anesthesiology, VU University Medical Center, Boelelaan 1117, 1081 HV Amsterdam, Netherlands; Laboratory for Physiology, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, Netherlands., Kwekkeboom RF; Laboratory for Physiology, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, Netherlands., Loer SA; Department of Anesthesiology, VU University Medical Center, Boelelaan 1117, 1081 HV Amsterdam, Netherlands., Boer C; Department of Anesthesiology, VU University Medical Center, Boelelaan 1117, 1081 HV Amsterdam, Netherlands., Bouwman RA; Department of Anesthesiology, VU University Medical Center, Boelelaan 1117, 1081 HV Amsterdam, Netherlands.
Jazyk: angličtina
Zdroj: Journal of diabetes research [J Diabetes Res] 2016; Vol. 2016, pp. 5205631. Date of Electronic Publication: 2015 Dec 28.
DOI: 10.1155/2016/5205631
Abstrakt: Preservation of myocardial perfusion during surgery is particularly important in patients with increased risk for perioperative complications, such as diabetes. Volatile anesthetics, like sevoflurane, have cardiodepressive effects and may aggravate cardiovascular complications. We investigated the effect of sevoflurane on myocardial perfusion and function in prediabetic rats. Rats were fed a western diet (WD; n = 18) or control diet (CD; n = 18) for 8 weeks and underwent (contrast) echocardiography to determine perfusion and function during baseline and sevoflurane exposure. Myocardial perfusion was estimated based on the product of microvascular filling velocity and blood volume. WD-feeding resulted in a prediabetic phenotype characterized by obesity, hyperinsulinemia, hyperlipidemia, glucose intolerance, and hyperglycemia. At baseline, WD-feeding impaired myocardial perfusion and systolic function compared to CD-feeding. Exposure of healthy rats to sevoflurane increased the microvascular filling velocity without altering myocardial perfusion but impaired systolic function. In prediabetic rats, sevoflurane did also not affect myocardial perfusion; however, it further impaired systolic function. Diet-induced prediabetes is associated with impaired myocardial perfusion and function in rats. While sevoflurane further impaired systolic function, it did not affect myocardial perfusion in prediabetic rats. Our findings suggest that sevoflurane anesthesia leads to uncoupling of myocardial perfusion and function, irrespective of the metabolic state.
Databáze: MEDLINE