Effects of osteoformin in the rapid distraction osteogenesis of rabbit mandibles.

Autor:	Dayisoylu EH; Baskent University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Bahcelievler, Ankara, Turkey., Pampu A; Baskent University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Bahcelievler, Ankara, Turkey., Senel FC; Baskent University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Bahcelievler, Ankara, Turkey., Onder E; Baskent University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Bahcelievler, Ankara, Turkey., Dolanmaz D; Baskent University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Bahcelievler, Ankara, Turkey., Altintas NY; Baskent University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Bahcelievler, Ankara, Turkey., Avunduk MC; Baskent University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Bahcelievler, Ankara, Turkey.
Jazyk:	angličtina
Zdroj:	JPMA. The Journal of the Pakistan Medical Association [J Pak Med Assoc] 2016 Feb; Vol. 66 (2), pp. 135-9.
Abstrakt:	Objective: To evaluate the effects of osteoformin on mineralisation and quality of the new bone formation during rapid distraction osteogenesis. Methods: This multi-centre study was conducted at the Karadeniz Technical University, Middle East Technical University and Selcuk University. The experimental study was conducted from January 2010 to September 2012 and comprised New-Zealand rabbits that were randomly divided into three groups. In group I distraction rate was 1 mm/day while in groups II and III distraction rates were 2mm/day and 1 mm/day. In groups I and II 100µg/kg osteoformin was injected after the latency period. Distraction region was evaluated by radiological, histomorphometrical and dual energy X-ray absorptiometry analyses. SPSS 17 was used for statistical analysis. Results: There were 18 rabbits with each of three groups having 6(33.3%). Accelerated bone healing was noted in groups I and II compared with group III (p<0.05). No significant differences were indicated between groups I and II (p>0.05). Conclusions: Local injection of osteoformin was effective in the craniomaxillofacial distraction osteogenesis in rabbits. Further experimental studies are recommended before using osteoformin on humans.
Databáze:	MEDLINE
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