Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes.

Autor: Imamura M; Laboratory for Endocrinology, Metabolism and Kidney Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan., Takahashi A; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan.; Laboratory for Omics Informatics, Omics Research Center, National Cerebral And Cardiovascular Center, Suita 565-8565, Japan., Yamauchi T; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan., Hara K; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan.; Department of Diabetes Endocrinology, Metabolism and Rheumatology, Tokyo Medical University, Tokyo 160-0023, Japan., Yasuda K; Department of Metabolic Disorder, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, Tokyo 162-8655, Japan., Grarup N; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark., Zhao W; Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6021, USA., Wang X; Saw Swee Hock School of Public Health, National University of Singapore, Singapore 138672, Singapore., Huerta-Chagoya A; Unidad de Biología Molecular y Medicina Genómica, Instituto de Investigaciones Biomédicas UNAM/Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City C.P.14000, Mexico., Hu C; Department of Endocrinology and Metabolism, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Diabetes Institute, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China., Moon S; Division of Structural and Functional Genomics, Center for Genome Science, National Institute of Health, Chungcheongbuk-do 28159, Korea., Long J; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37203-1738, USA., Kwak SH; Department of Internal Medicine, Seoul National University Hospital, Seoul 03080, Korea., Rasheed A; Center for Non-Communicable Diseases, Karachi, Pakistan., Saxena R; Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA., Ma RC; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.; Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, China.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China., Okada Y; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan.; Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan., Iwata M; First Department of Internal Medicine, University of Toyama, Toyama 930-0194, Japan.; Health Administration Center, University of Toyama, Toyama 930-0194, Japan., Hosoe J; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan., Shojima N; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan., Iwasaki M; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan., Fujita H; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan., Suzuki K; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan., Danesh J; Department of Public Health and Primary Care, University of Cambridge CB1 8RN, UK.; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus Hinxton, Cambridge CB10 1RQ, UK.; NIHR Blood and Transplant Research Unit in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK., Jørgensen T; Research Centre for Prevention and Health, Capital Region of Denmark, Glostrup DK-2600, Denmark.; Faculty of Health and Medical Sciences, Department of Public Health, University of Copenhagen, Copenhagen 2200, Denmark.; Faculty of Medicine, University of Aalborg, Aalborg 9220, Denmark., Jørgensen ME; Steno Diabetes Center, Gentofte 2820, Denmark., Witte DR; Department of Public Health, Aarhus University, Aarhus 8000, Denmark.; Danish Diabetes Academy, Odense 5000, Denmark., Brandslund I; Department of Clinical Biochemistry, Lillebaelt Hospital, Vejle 7100, Denmark.; Institute of Regional Health Research, University of Southern Denmark, Odense 5230, Denmark., Christensen C; Medical Department, Lillebaelt Hospital, Vejle 7100, Denmark., Hansen T; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark., Mercader JM; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA.; Joint BSC-CRG-IRB Research Program in Computational Biology, Barcelona Supercomputing Center, Barcelona 08034, Spain.; Center for Human Genetic Research and Diabetes Research Center (Diabetes Unit), Massachusetts General Hospital, Boston, Massachusetts 02114, USA., Flannick J; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA.; Department of Molecular Biology, Harvard Medical School, Boston, Massachusetts 02115, USA., Moreno-Macías H; Universidad Autónomas Metropolitana, Mexico City 09340, Mexico., Burtt NP; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA., Zhang R; Department of Endocrinology and Metabolism, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Diabetes Institute, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China., Kim YJ; Division of Structural and Functional Genomics, Center for Genome Science, National Institute of Health, Chungcheongbuk-do 28159, Korea., Zheng W; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37203-1738, USA., Singh JR; Central University of Punjab, Bathinda, Punjab 151001, India., Tam CH; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China., Hirose H; Health Center, Keio University, Tokyo 160-8582, Japan., Maegawa H; Department of Medicine, Shiga University of Medical Science, Otsu 520-2192, Japan., Ito C; Grand Tower Medical Court Life Care Clinic, Hiroshima 730-0012, Japan., Kaku K; Department of Internal Medicine, Kawasaki Medical School, Kurashiki 701-0192, Japan., Watada H; Department of Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan.; Sportology Center, Juntendo University Graduate School of Medicine, Tokyo 113-0034, Japan., Tanaka Y; Division of Metabolism and Endocrinology, Department of Internal Medicine, St Marianna University School of Medicine, Kawasaki 216-8511, Japan., Tobe K; First Department of Internal Medicine, University of Toyama, Toyama 930-0194, Japan., Kawamori R; Sportology Center, Juntendo University Graduate School of Medicine, Tokyo 113-0034, Japan., Kubo M; RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan., Cho YS; Department of Biomedical Science, Hallym University, Chunchon, Gangwon-do 24252, Republic of Korea., Chan JC; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.; Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, China.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China., Sanghera D; Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA.; Department of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, n., Frossard P; Center for Non-Communicable Diseases, Karachi, Pakistan., Park KS; Department of Internal Medicine, Seoul National University Hospital, Seoul 03080, Korea.; Department of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, Korea.; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 03080, Korea., Shu XO; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37203-1738, USA., Kim BJ; Division of Structural and Functional Genomics, Center for Genome Science, National Institute of Health, Chungcheongbuk-do 28159, Korea., Florez JC; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA.; Center for Human Genetic Research and Diabetes Research Center (Diabetes Unit), Massachusetts General Hospital, Boston, Massachusetts 02114, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA., Tusié-Luna T; Unidad de Biología Molecular y Medicina Genómica, Instituto de Investigaciones Biomédicas UNAM/Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City C.P.14000, Mexico., Jia W; Department of Endocrinology and Metabolism, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Diabetes Institute, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China., Tai ES; Saw Swee Hock School of Public Health, National University of Singapore, Singapore 138672, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.; Duke-National University of Singapore Graduate School, Singapore 169857, Singapore., Pedersen O; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark., Saleheen D; Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6021, USA.; Center for Non-Communicable Diseases, Karachi, Pakistan., Maeda S; Laboratory for Endocrinology, Metabolism and Kidney Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan.; Department of Advanced Genomic and Laboratory Medicine, Graduate School of Medicine, University of the Ryukyus, Nishihara 903-0215, Japan.; Division of Clinical Laboratory and Blood Transfusion, University of the Ryukyus Hospital, Nishihara 903-0215, Japan., Kadowaki T; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2016 Jan 28; Vol. 7, pp. 10531. Date of Electronic Publication: 2016 Jan 28.
DOI: 10.1038/ncomms10531
Abstrakt: Genome-wide association studies (GWAS) have identified more than 80 susceptibility loci for type 2 diabetes (T2D), but most of its heritability still remains to be elucidated. In this study, we conducted a meta-analysis of GWAS for T2D in the Japanese population. Combined data from discovery and subsequent validation analyses (23,399 T2D cases and 31,722 controls) identify 7 new loci with genome-wide significance (P<5 × 10(-8)), rs1116357 near CCDC85A, rs147538848 in FAM60A, rs1575972 near DMRTA1, rs9309245 near ASB3, rs67156297 near ATP8B2, rs7107784 near MIR4686 and rs67839313 near INAFM2. Of these, the association of 4 loci with T2D is replicated in multi-ethnic populations other than Japanese (up to 65,936 T2Ds and 158,030 controls, P<0.007). These results indicate that expansion of single ethnic GWAS is still useful to identify novel susceptibility loci to complex traits not only for ethnicity-specific loci but also for common loci across different ethnicities.
Databáze: MEDLINE