[Value of CK5/6, CK14, ER and PR detection in differential diagnosis of intraductal proliferative lesions of the breast].

Autor:	Niu F; Department of Breast Pathology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China., Wang L; Department of Breast Pathology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China., Zhang W; Department of Breast Pathology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China., Lyu S; Department of Breast Pathology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China., Niu Y; Department of Breast Pathology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China; Email: yunniu2000@126.com.
Jazyk:	čínština
Zdroj:	Zhonghua zhong liu za zhi [Chinese journal of oncology] [Zhonghua Zhong Liu Za Zhi] 2015 Oct; Vol. 37 (10), pp. 749-52.
Abstrakt:	Objective: To investigate the expression of high-molecular-weight keratins CK5/6, CK14, estrogen receptor (ER) and progesterone receptor (PR) in differential diagnosis of simple ductal hyperplasia (UDH), atypical ductal hyperplasia (ADH) and low-grade ductal carcinoma in situ (low-grade DCIS) . Methods: The clinicopathological data of twenty cases of atypical ductal epithelial hyperplasia (ADH) with focal cancerization changed into low-grade DCIS diagnosed at Tianjin Medical University Cancer Institute and Hospital between January 2013 and February 2014 were reviewed and analyzed. The expressions of CK5/6, CK14, ER and PR were detected by immunohistochemistry. Results: Positive expressions of CK5/6 and CK14 were seen in UDH showing a mosaic pattern, while negative expression in ADH and low-grade DCIS. In addition, CK5/6 and CK14 were positively expressed in the myoepithelial cells of UDH, ADH and low-grade DCIS. Positive expressions of ER and PR were observed in UDH, ADH and low-grade DCIS. But they presented diffuse and homogeneous strong positive expression in ADH and variable positive expression in UDH. Conclusion: In the intraductal proliferative lesions of the breast, the use of combined detection of the expression of CK5/6, CK14, ER and PR is of practical significance in the differential diagnosis of UDH, ADH and low-grade DCIS.
Databáze:	MEDLINE
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