Evolutionary signals of selection on cognition from the great tit genome and methylome.

Autor: Laine VN; Department of Animal Ecology, Netherlands Institute of Ecology (NIOO-KNAW), P.O. Box 50, 6700AB Wageningen, The Netherlands., Gossmann TI; Department of Animal and Plant Sciences, University of Sheffield, Sheffield S10 2TN, UK., Schachtschneider KM; Animal Breeding and Genomics Centre, Wageningen University, P.O. Box 338, 6700AH Wageningen, The Netherlands.; Department of Animal Sciences, University of Illinois, Urbana, Illinois 61801, USA., Garroway CJ; Edward Grey Institute, Department of Zoology, University of Oxford, Oxford OX1 3PS, UK., Madsen O; Animal Breeding and Genomics Centre, Wageningen University, P.O. Box 338, 6700AH Wageningen, The Netherlands., Verhoeven KJ; Department of Terrestrial Ecology, Netherlands Institute of Ecology (NIOO-KNAW), P.O. Box 50, 6700AB Wageningen, The Netherlands., de Jager V; Department of Animal Ecology, Netherlands Institute of Ecology (NIOO-KNAW), P.O. Box 50, 6700AB Wageningen, The Netherlands., Megens HJ; Animal Breeding and Genomics Centre, Wageningen University, P.O. Box 338, 6700AH Wageningen, The Netherlands., Warren WC; The Genome Institute, Washington University School of Medicine, St Louis, Missouri 63108, USA., Minx P; The Genome Institute, Washington University School of Medicine, St Louis, Missouri 63108, USA., Crooijmans RP; Animal Breeding and Genomics Centre, Wageningen University, P.O. Box 338, 6700AH Wageningen, The Netherlands., Corcoran P; Department of Animal and Plant Sciences, University of Sheffield, Sheffield S10 2TN, UK., Sheldon BC; Edward Grey Institute, Department of Zoology, University of Oxford, Oxford OX1 3PS, UK., Slate J; Department of Animal and Plant Sciences, University of Sheffield, Sheffield S10 2TN, UK., Zeng K; Department of Animal and Plant Sciences, University of Sheffield, Sheffield S10 2TN, UK., van Oers K; Department of Animal Ecology, Netherlands Institute of Ecology (NIOO-KNAW), P.O. Box 50, 6700AB Wageningen, The Netherlands., Visser ME; Department of Animal Ecology, Netherlands Institute of Ecology (NIOO-KNAW), P.O. Box 50, 6700AB Wageningen, The Netherlands.; Animal Breeding and Genomics Centre, Wageningen University, P.O. Box 338, 6700AH Wageningen, The Netherlands., Groenen MA; Animal Breeding and Genomics Centre, Wageningen University, P.O. Box 338, 6700AH Wageningen, The Netherlands.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2016 Jan 25; Vol. 7, pp. 10474. Date of Electronic Publication: 2016 Jan 25.
DOI: 10.1038/ncomms10474
Abstrakt: For over 50 years, the great tit (Parus major) has been a model species for research in evolutionary, ecological and behavioural research; in particular, learning and cognition have been intensively studied. Here, to provide further insight into the molecular mechanisms behind these important traits, we de novo assemble a great tit reference genome and whole-genome re-sequence another 29 individuals from across Europe. We show an overrepresentation of genes related to neuronal functions, learning and cognition in regions under positive selection, as well as increased CpG methylation in these regions. In addition, great tit neuronal non-CpG methylation patterns are very similar to those observed in mammals, suggesting a universal role in neuronal epigenetic regulation which can affect learning-, memory- and experience-induced plasticity. The high-quality great tit genome assembly will play an instrumental role in furthering the integration of ecological, evolutionary, behavioural and genomic approaches in this model species.
Databáze: MEDLINE