Low sulfide levels and a high degree of cystathionine β-synthase (CBS) activation by S-adenosylmethionine (SAM) in the long-lived naked mole-rat.

Autor:	Dziegelewska M; Genome Analysis, Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), Beutenbergstraße 11, 07745 Jena, Germany. Electronic address: maja.dziegelewska@leibniz-fli.de., Holtze S; Reproduction Management, Leibniz Institute for Zoo & Wildlife Research, Alfred-Kowalke-Straße 17, 10315 Berlin, Germany. Electronic address: holtze@izw-berlin.de., Vole C; Department of General Zoology, University of Duisburg-Essen, Universitätsstraße 2, 45141 Essen, Germany. Electronic address: christiane.vole@uni-due.de., Wachter U; Klinik für Anästhesiologie, Universitätsklinikum, Albert-Einstein-Allee 23, 89081 Ulm, Germany. Electronic address: ulrich.wachter@uni-ulm.de., Menzel U; Leibniz Institute for Natural Product Research and Infection Biology - Hans-Knöll-Institute (HKI), Beutenbergstraße 11a, 07745 Jena, Germany. Electronic address: Uwe.Menzel@hki-jena.de., Morhart M; Reproduction Management, Leibniz Institute for Zoo & Wildlife Research, Alfred-Kowalke-Straße 17, 10315 Berlin, Germany. Electronic address: morhart@izw-berlin.de., Groth M; Genome Analysis, Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), Beutenbergstraße 11, 07745 Jena, Germany. Electronic address: marco.groth@leibniz-fli.de., Szafranski K; Genome Analysis, Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), Beutenbergstraße 11, 07745 Jena, Germany. Electronic address: karol.szafranski@leibniz-fli.de., Sahm A; Genome Analysis, Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), Beutenbergstraße 11, 07745 Jena, Germany. Electronic address: arne.sahm@leibniz-fli.de., Sponholz C; Genome Analysis, Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), Beutenbergstraße 11, 07745 Jena, Germany; Department of Anaesthesiology and Intensive Care Therapy, Jena University Hospital, Erlanger Allee 101, 07747 Jena, Germany. Electronic address: Christoph.Sponholz@med.uni-jena.de., Dammann P; Department of General Zoology, University of Duisburg-Essen, Universitätsstraße 2, 45141 Essen, Germany; Central Animal Laboratory, University Hospital, University of Duisburg-Essen, Hufelandstraße 55, 45122 Essen, Germany. Electronic address: Philip.Dammann@uk-essen.de., Huse K; Genome Analysis, Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), Beutenbergstraße 11, 07745 Jena, Germany. Electronic address: klaus.huse@leibniz-fli.de., Hildebrandt T; Reproduction Management, Leibniz Institute for Zoo & Wildlife Research, Alfred-Kowalke-Straße 17, 10315 Berlin, Germany. Electronic address: HILDEBRANDT@izw-berlin.de., Platzer M; Genome Analysis, Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), Beutenbergstraße 11, 07745 Jena, Germany. Electronic address: matthias.platzer@leibniz-fli.de.
Jazyk:	angličtina
Zdroj:	Redox biology [Redox Biol] 2016 Aug; Vol. 8, pp. 192-8. Date of Electronic Publication: 2016 Jan 14.
DOI:	10.1016/j.redox.2016.01.008
Abstrakt:	Hydrogen sulfide (H2S) is a gaseous signalling molecule involved in many physiological and pathological processes. There is increasing evidence that H2S is implicated in aging and lifespan control in the diet-induced longevity models. However, blood sulfide concentration of naturally long-lived species is not known. Here we measured blood sulfide in the long-lived naked mole-rat and five other mammalian species considerably differing in lifespan and found a negative correlation between blood sulfide and maximum longevity residual. In addition, we show that the naked mole-rat cystathionine β-synthase (CBS), an enzyme whose activity in the liver significantly contributes to systemic sulfide levels, has lower activity in the liver and is activated to a higher degree by S-adenosylmethionine compared to other species. These results add complexity to the understanding of the role of H2S in aging and call for detailed research on naked mole-rat transsulfuration. (Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze:	MEDLINE
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