| Autor: |
Gradella Villalva D; Dipartimento di Chimica, Università degli Studi di Roma 'Sapienza' , P.le Aldo Moro 5, 00185 Roma, Italy., Diociaiuti M; Dipartimento di Tecnologia e Salute, Istituto Superiore di Sanità , Viale Regina Elena 299, 00161 Roma, Italy., Giansanti L; Dipartimento di Scienze Fisiche e Chimiche, Università degli Studi dell'Aquila , Via Vetoio, 67100 Coppito, AQ, Italy., Petaccia M; Dipartimento di Scienze Fisiche e Chimiche, Università degli Studi dell'Aquila , Via Vetoio, 67100 Coppito, AQ, Italy., Bešker N; CINECA, SCAI-Super Computing Applications and Innovation Department, Via dei Tizii, 6, 00185, Rome, Italy., Mancini G; CNR-Istituto di Metodologie Chimiche, Via Salaria km 29.300, 00016 Monterotondo Scalo, Roma, Italy. |
| Abstrakt: |
Pyrene lipids are useful tools to investigate membrane organization and intracellular lipid trafficking. The molecular interactions controlling the organization of lipid monolayers composed of a cationic amphiphile tagged with a pyrene residue and a saturated or unsaturated phospholipid, namely, 1,2-dimyristoyl-sn-glycero-3-phosphocholine and 1,2-dioleoyl-sn-glycero-3-phosphocholine, were investigated by Langmuir trough isotherms to understand how the molecular structure of the components and their relative amount affect the physicochemical properties of lipid monolayers. The obtained results show that the cationic headgroups and unsaturation of hydrophobic chains strongly affect the organization of the lipid monolayer as a function of the amount of components. On the other hand, the presence of the pyrene moiety does not seem to have a marked influence on the interaction within lipid assembly. |
