2-(2,4-Dioxy-1,2,3,4-Tetrahydropyrimidin-1-yl)-N-(4-Phenoxyphenyl)-Acetamides as a Novel Class of Cytomegalovirus Replication Inhibitors.

Autor:	Babkov DA; Volgograd State Medical University, Pavshikh Bortsov Sq., 1, Volgograd 400131, Russia., Paramonova MP; Volgograd State Medical University, Pavshikh Bortsov Sq., 1, Volgograd 400131, Russia., Ozerov AA; Volgograd State Medical University, Pavshikh Bortsov Sq., 1, Volgograd 400131, Russia., Khandazhinskaya AL; Engelhardt Institute of Molecular Biology, Russian Academy of Science, Vavilov Str., 32, Moscow, 119991 , Russia., Snoeck R; Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, Leuven B-3000, Belgium., Andrei G; Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, Leuven B-3000, Belgium., Novikov MS; Volgograd State Medical University, Pavshikh Bortsov Sq., 1, Volgograd 400131, Russia.
Jazyk:	angličtina
Zdroj:	Acta naturae [Acta Naturae] 2015 Oct-Dec; Vol. 7 (4), pp. 142-5.
Abstrakt:	A series of novel uracil derivatives, bearing N-(4-phenoxyphenyl)acetamide moiety at N3 of a pyrimidine ring, has been synthesized. Their antiviral activity has been evaluated. It has been found that the novel compounds possess high inhibitory activity against replication of human cytomegalovirus (AD-169 and Davis strains) in HEL cell cultures. In addition, some of the derivatives proved to be inhibitory against varicella zoster virus.
Databáze:	MEDLINE
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