| Autor: |
Vinogradova TV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences., Chernov IP; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences., Monastyrskaya GS; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences., Kondratyeva LG; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences., Sverdlov ED; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences. |
| Jazyk: |
angličtina |
| Zdroj: |
Acta naturae [Acta Naturae] 2015 Oct-Dec; Vol. 7 (4), pp. 46-55. |
| Abstrakt: |
Great successes in identification and deciphering of mechanisms of the adult stem cells regulation have given rise to the idea that stem cells can also function in tumors as central elements of their development, starting from the initial stage and continuing until metastasis. Such cells were called cancer stem cells (CSCs). Over the course of intense discussion, the CSCs hypothesis gradually began to be perceived as an obvious fact. Recently, the existence of CSCs has been indeed confirmed in a number of works. However, when are CSCs universal prerequisites of tumors and to what extent their role is essential for tumor evolution remains an issue far from resolved. Likewise, the problem of potential use of CSCs as therapeutic targets remains unsolved. The present review attempts to analyze the issue of cancer stem cells and the potential of targeting them in tumor therapy. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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