| Autor: |
Walkling WD, Holmes DG, Cressman WA, Dix RK, Piperno E, Mosher AH |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of pharmaceutical sciences [J Pharm Sci] 1978 Jul; Vol. 67 (7), pp. 948-50. |
| DOI: |
10.1002/jps.2600670719 |
| Abstrakt: |
Plasma intact 14C-mixidine levels in rats increased when the drug was administered intraduodenally with 1:3 and 1:5 molar ratios of 2-naphthalenesulfonic acid. Upon histological examination of the duodenums, similar doses of mixidine combined with 2-naphthalenesulfonic acid produced no dose-related lesions. These and previous observations demonstrate that mixidine absorption may be enhanced by ion-pair formation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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