Atrial metabolism and tissue perfusion as determinants of electrical and structural remodelling in atrial fibrillation.

Autor:	Opacic D; Department of Physiology, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands., van Bragt KA; Department of Physiology, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands., Nasrallah HM; Department of Physiology, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands., Schotten U; Department of Physiology, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands., Verheule S; Department of Physiology, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands s.verheule@maastrichtuniversity.nl.
Jazyk:	angličtina
Zdroj:	Cardiovascular research [Cardiovasc Res] 2016 Apr 01; Vol. 109 (4), pp. 527-41. Date of Electronic Publication: 2016 Jan 19.
DOI:	10.1093/cvr/cvw007
Abstrakt:	Atrial fibrillation (AF) is the most common tachyarrhythmia in clinical practice. Over decades of research, a vast amount of knowledge has been gathered about the causes and consequences of AF related to cellular electrophysiology and features of the tissue structure that influence the propagation of fibrillation waves. Far less is known about the role of myocyte metabolism and tissue perfusion in the pathogenesis of AF. However, the rapid rates of electrical activity and contraction during AF must present an enormous challenge to the energy balance of atrial myocytes. This challenge can be met by scaling back energy demand and by increasing energy supply, and there are several indications that both phenomena occur as a result of AF. Still, there is ample evidence that these adaptations fall short of redressing this imbalance, which may represent a driving force for atrial electrical as well as structural remodelling. In addition, several 'metabolic diseases' such as diabetes, obesity, and abnormal thyroid function precipitate some well-known 'culprits' of the AF substrate such as myocyte hypertrophy and fibrosis, while some other AF risk factors, such as heart failure, affect atrial metabolism. This review provides an overview of metabolic and vascular alterations in AF and their involvement in its pathogenesis. (Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2016. For permissions please email: journals.permissions@oup.com.)
Databáze:	MEDLINE
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