Ertapenem resistance in 2 tertiary-care hospitals: Microbiology, epidemiology, and risk factors.

Autor:	Maldonado N; Laboratorio Médico de Referencia, Medellín, Colombia. Electronic address: investigaciones@labmedico.com., Castro B; Dirección de Gestión de Conocimiento, Universidad CES, Medellín, Colombia., Berrio I; Clínica El Rosario Sede Centro, Medellín, Colombia., Manjarrés M; Clínica El Rosario Sede Tesoro, Medellín, Colombia., Robledo C; Laboratorio Médico de Referencia, Medellín, Colombia; Clínica El Rosario, Medellín, Colombia., Robledo J; Laboratorio Médico de Referencia, Medellín, Colombia; Clínica El Rosario, Medellín, Colombia; Unidad de Bacteriología y Micobacterias, Corporación para Investigaciones Biológicas (CIB), Escuela de Ciencias de la Salud, Universidad Pontificia Bolivariana, Medellín, Colombia.
Jazyk:	English; Spanish; Castilian
Zdroj:	Enfermedades infecciosas y microbiologia clinica [Enferm Infecc Microbiol Clin] 2017 Oct; Vol. 35 (8), pp. 511-515. Date of Electronic Publication: 2016 Jan 06.
DOI:	10.1016/j.eimc.2015.11.009
Abstrakt:	Introduction: Carbapenems resistance is a growing phenomenon and a threat to public health because of the reduced therapeutic options for resistant infections. Methods: A retrospective case-control study was conducted in 2 tertiary-care hospitals in Medellín, Colombia. Fifty patients infected with ertapenem-resistant enterobacteriaceae were compared with a control group consisting of 100 patients with infections caused by ertapenem susceptible enterobacteriaceae. A multivariate logistic regression model was used to identify factors that best explain ertapenem-resistant enterobacteriaceae infections. Results: The factors associated with ertapenem-resistant enterobacteriaceae infections were prior exposure to carbapenems (adjusted OR 3.43; 95% IC 1.08-10.87) and prior exposure to cefepime (adjusted OR 6.46; 95% IC 1.08-38.38). Conclusion: Prior exposure to antibiotics is the factor that best explains the ertapenem-resistant enterobacteriaceae infection in this population, highlighting the importance of antimicrobial stewardship programs in hospitals. (Copyright © 2015 Elsevier España, S.L.U. y Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. All rights reserved.)
Databáze:	MEDLINE
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