Hyaluronate nanoparticles included in polymer films for the prolonged release of vitamin E for the management of skin wounds.

Autor: Pereira GG; Faculty the Pharmacy, University Federal do Rio Grande do Sul, Porto Alegre, Brazil., Detoni CB; Faculty the Pharmacy, University Federal do Rio Grande do Sul, Porto Alegre, Brazil., Balducci AG; Biopharmanet-TEC, Interdepartmental Centre for Innovation in Health Products, University of Parma, Italy; Department of Pharmacy, University of Parma, Italy., Rondelli V; Department of Medical Biotechnology and Translational Medicine, University of Milan, Italy., Colombo P; Department of Pharmacy, University of Parma, Italy., Guterres SS; Faculty the Pharmacy, University Federal do Rio Grande do Sul, Porto Alegre, Brazil., Sonvico F; Biopharmanet-TEC, Interdepartmental Centre for Innovation in Health Products, University of Parma, Italy; Department of Pharmacy, University of Parma, Italy; Graduate School of Health - Pharmacy, University of Technology Sydney, Australia. Electronic address: fabio.sonvico@uts.edu.au.
Jazyk: angličtina
Zdroj: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2016 Feb 15; Vol. 83, pp. 203-11. Date of Electronic Publication: 2016 Jan 06.
DOI: 10.1016/j.ejps.2016.01.002
Abstrakt: Lecithin and hyaluronic acid were used for the preparation of polysaccharide decorated nanoparticles loaded with vitamin E using the cationic lipid dioctadecyldimethylammonium bromide (DODMA). Nanoparticles showed mean particle size in the range 130-350 nm and narrow size distribution. Vitamin E encapsulation efficiency was higher than 99%. These nanoparticles were incorporated in polymeric films containing Aloe vera extract, hyaluronic acid, sodium alginate, polyethyleneoxide (PEO) and polyvinylalcohol (PVA) as an innovative treatment in skin wounds. Films were thin, flexible, resistant and suitable for application on burn wounds. Additionally, in vitro occlusion study highlighted the dependence of the occlusive effect on the presence of nanoparticles. The results obtained show that the bioadhesive films containing vitamin E acetate and Aloe vera could be an innovative therapeutic system for the treatment of skin wounds, such as burns. The controlled release of the vitamin along with a reduction in water loss through damaged skin provided by the nanoparticle-loaded polymer film are considered important features for an improvement in wound healing and skin regeneration.
(Copyright © 2015 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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