Cutaneous squamous cell carcinoma progression is associated with decreased GATA-3 immunohistochemical staining.

Autor: Solus JF; Department of Pathology and Immunology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA., Hassan K; Department of Pathology and Immunology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA., Lee SJ; Internal Medicine Division of Dermatology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA., Hsi AC; Department of Pathology and Immunology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA., Rosman IS; Department of Pathology and Immunology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.; Internal Medicine Division of Dermatology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA., Dehmeri S; Internal Medicine Division of Dermatology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA., Schaffer A; Department of Pathology and Immunology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.; Internal Medicine Division of Dermatology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Jazyk: angličtina
Zdroj: Journal of cutaneous pathology [J Cutan Pathol] 2016 Apr; Vol. 43 (4), pp. 347-53. Date of Electronic Publication: 2016 Feb 10.
DOI: 10.1111/cup.12667
Abstrakt: Background: The GATA family of transcription factors is an essential regulator of cellular proliferation and differentiation. In the skin, GATA-3 is critical for epidermal stratification and maintenance of barrier function. A role for GATA-3 in the development of human cutaneous squamous cell carcinoma (SCC) is not known. Here, we investigated GATA-3 immunohistochemical staining in premalignant and invasive cutaneous SCC from sun-exposed and sun-protected skin.
Methods: GATA-3 immunohistochemistry was performed on actinic keratoses (AK) (n = 19), in situ squamous cell carcinomas with actinic [SCCIS (A)] (n = 9) or bowenoid features [SCCIS (B)] (n = 17), well-, moderately and poorly differentiated SCC (n = 36), Bowenoid papulosis of the perineum (n = 15) and penile SCC (pSCC) (n = 10).
Results: We found that GATA-3 immunohistochemical staining is progressively lost in sun-exposed skin as neoplasia progresses from pre-cancerous AK to SCCIS (A), and ultimately, to SCC, which shows near absent GATA-3 staining. This reduction in GATA-3 staining is independent of histological grade in SCC. Only slight down-regulation of GATA-3 was seen in all cases of SCCIS (B) and Bowenoid papulosis, while near absent GATA-3 expression was seen in pSCC.
Conclusion: We propose that decreased GATA-3 immunohistochemical staining is associated with cutaneous SCC progression on both sun-exposed and sun-protected sites.
(© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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