Association of ACTN3 R577X but not ACE I/D gene variants with elite rugby union player status and playing position.

Autor:	Heffernan SM; MMU Sports Genomics Laboratory, Manchester Metropolitan University, Crewe, United Kingdom; shane.heffernan@stu.mmu.ac.uk., Kilduff LP; A-STEM, College of Engineering, Swansea University, Swansea, United Kingdom;, Erskine RM; Research Institute for Sport & Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom; Institute of Sport, Exercise and Health, University College London, London, United Kingdom;, Day SH; MMU Sports Genomics Laboratory, Manchester Metropolitan University, Crewe, United Kingdom;, McPhee JS; School of Healthcare Science, Manchester Metropolitan University, Manchester, United Kingdom;, McMahon GE; MMU Sports Genomics Laboratory, Manchester Metropolitan University, Crewe, United Kingdom; Northern Ireland Sports Institute, Newtownabbey, Belfast, United Kingdom;, Stebbings GK; MMU Sports Genomics Laboratory, Manchester Metropolitan University, Crewe, United Kingdom;, Neale JP; MMU Sports Genomics Laboratory, Manchester Metropolitan University, Crewe, United Kingdom;, Lockey SJ; MMU Sports Genomics Laboratory, Manchester Metropolitan University, Crewe, United Kingdom;, Ribbans WJ; Division of Sport, Exercise and Life Science, University of Northampton, Northampton, United Kingdom;, Cook CJ; School of Sport, Health and Exercise Sciences, Bangor University, Bangor, United Kingdom;, Vance B; Institute of Cardiovascular & Medical Sciences University of Glasgow, Glasgow, United Kingdom;, Raleigh SM; Division of Sport, Exercise and Life Science, University of Northampton, Northampton, United Kingdom;, Roberts C; Medical and Scientific Department, South African Rugby Union, Cape Town, South Africa; Discipline of Sports Science, Faculty of Health Sciences, University of Kwazulu-Natal, Durban, South Africa;, Bennett MA; A-STEM, College of Engineering, Swansea University, Swansea, United Kingdom;, Wang G; Centre for Sport and Exercise Science and Medicine (SESAME), University of Brighton, Brighton, United Kingdom; and., Collins M; MRC/UCT Research Unit for Exercise Science and Sports Medicine, University of Cape Town (UCT), Cape Town, South Africa., Pitsiladis YP; Centre for Sport and Exercise Science and Medicine (SESAME), University of Brighton, Brighton, United Kingdom; and., Williams AG; MMU Sports Genomics Laboratory, Manchester Metropolitan University, Crewe, United Kingdom; Institute of Sport, Exercise and Health, University College London, London, United Kingdom;
Jazyk:	angličtina
Zdroj:	Physiological genomics [Physiol Genomics] 2016 Mar; Vol. 48 (3), pp. 196-201. Date of Electronic Publication: 2016 Jan 12.
DOI:	10.1152/physiolgenomics.00107.2015
Abstrakt:	We aimed to quantify the ACE I/D and ACTN3 R577X (rs1815739) genetic variants in elite rugby athletes (rugby union and league) and compare genotype frequencies to controls and between playing positions. The rugby athlete cohort consisted of 507 Caucasian men, including 431 rugby union athletes that for some analyses were divided into backs and forwards and into specific positional groups: front five, back row, half backs, centers, and back three. Controls were 710 Caucasian men and women. Real-time PCR of genomic DNA was used to determine genotypes using TaqMan probes and groups were compared using χ(2) and odds ratio (OR) statistics. Correction of P values for multiple comparisons was according to Benjamini-Hochberg. There was no difference in ACE I/D genotype between groups. ACTN3 XX genotype tended to be underrepresented in rugby union backs (15.7%) compared with forwards (24.8%, P = 0.06). Interestingly, the 69 back three players (wings and full backs) in rugby union included only six XX genotype individuals (8.7%), with the R allele more common in the back three (68.8%) than controls (58.0%; χ(2) = 6.672, P = 0.04; OR = 1.60) and forwards (47.5%; χ(2) = 11.768, P = 0.01; OR = 2.00). Association of ACTN3 R577X with playing position in elite rugby union athletes suggests inherited fatigue resistance is more prevalent in forwards, while inherited sprint ability is more prevalent in backs, especially wings and full backs. These results also demonstrate the advantage of focusing genetic studies on a large cohort within a single sport, especially when intrasport positional differences exist, instead of combining several sports with varied demands and athlete characteristics. (Copyright © 2016 the American Physiological Society.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu