Modified protocol including topical minocycline in orabase to manage medication-related osteonecrosis of the jaw cases.

Autor: Karasneh JA; Department of Oral Medicine and Orofacial Pain, Division of Diagnostic Sciences, University of Southern California, Los Angeles, CA, USA. jumana2003@yahoo.com., Al-Eryani K; Department of Oral Medicine and Orofacial Pain, Division of Diagnostic Sciences, University of Southern California, Los Angeles, CA, USA., Clark GT; Department of Oral Medicine and Orofacial Pain, Division of Diagnostic Sciences, University of Southern California, Los Angeles, CA, USA., Sedghizadeh PP; Centre for Biofilms, University of Southern California, Los Angeles, CA, USA.
Jazyk: angličtina
Zdroj: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology [J Oral Pathol Med] 2016 Oct; Vol. 45 (9), pp. 718-720. Date of Electronic Publication: 2016 Jan 11.
DOI: 10.1111/jop.12419
Abstrakt: Objective: Management of medication-related osteone-crosis of the jaw (MRONJ) with active infection can be a serious challenge for clinicians. Based on Association of Oral and Maxillofacial Surgeons (AAOMS) recommendations, we have tested a modified treatment protocol using topical minocycline.
Study Design: Five patients diagnosed with stage II or III MRONJ lesions were willing to consent to our protocol. In addition to conventional treatment as suggested by the AAOMS, such as, surgical debridement, chlorhexidine irrigation, and systemic antibiotics, we applied 10% minocycline to the lesions once a week for sustained local antibiotic delivery.
Results: All five patients reported pain relief after the first minocycline application. Complete healing occurred in three patients; case three healed completely after the third application, one case continues to improve toward resolution and one withdraws due to other non-relevant medical problem.
Conclusions: In this study, we are reporting favorable results using a modified protocol with topical minocycline to treat MRONJ lesions.
(© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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