Investigating cerebral oedema using poroelasticity.

Autor: Vardakis JC; Department of Mechanical Engineering, University College London, Torrington Place, London WC1E 7JE, UK., Chou D; Institute of Biomedical Engineering & Department of Engineering Science, University of Oxford, Oxford OX1 3PJ, UK., Tully BJ; First Light Fusion Ltd., Begbroke Science Park, Begbroke, Oxfordshire OX5 1PF, UK., Hung CC; Stroke Center and Department of Neurology, Chang Gung Memorial Hospital, Linkou Medical Center and College of Medicine, Taoyuan, Taiwan; Department of Electrical Engineering, College of Engineering, Chang Gung University, Taoyuan, Taiwan., Lee TH; Stroke Center and Department of Neurology, Chang Gung Memorial Hospital, Linkou Medical Center and College of Medicine, Taoyuan, Taiwan., Tsui PH; Department of Medical Imaging and Radiological Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Medical Imaging Research Center, Institute for Radiological Research, Chang Gung University and Chang Gung Memorial Hospital, Taoyuan, Taiwan., Ventikos Y; Department of Mechanical Engineering, University College London, Torrington Place, London WC1E 7JE, UK. Electronic address: y.ventikos@ucl.ac.uk.
Jazyk: angličtina
Zdroj: Medical engineering & physics [Med Eng Phys] 2016 Jan; Vol. 38 (1), pp. 48-57. Date of Electronic Publication: 2015 Dec 31.
DOI: 10.1016/j.medengphy.2015.09.006
Abstrakt: Cerebral oedema can be classified as the tangible swelling produced by expansion of the interstitial fluid volume. Hydrocephalus can be succinctly described as the abnormal accumulation of cerebrospinal fluid (CSF) within the brain which ultimately leads to oedema within specific sites of parenchymal tissue. Using hydrocephalus as a test bed, one is able to account for the necessary mechanisms involved in the interaction between oedema formation and cerebral fluid production, transport and drainage. The current state of knowledge about integrative cerebral dynamics and transport phenomena indicates that poroelastic theory may provide a suitable framework to better understand various diseases. In this work, Multiple-Network Poroelastic Theory (MPET) is used to develop a novel spatio-temporal model of fluid regulation and tissue displacement within the various scales of the cerebral environment. The model is applied through two formats, a one-dimensional finite difference - Computational Fluid Dynamics (CFD) coupling framework, as well as a two-dimensional Finite Element Method (FEM) formulation. These are used to investigate the role of endoscopic fourth ventriculostomy in alleviating oedema formation due to fourth ventricle outlet obstruction (1D coupled model) in addition to observing the capability of the FEM template in capturing important characteristics allied to oedema formation, like for instance in the periventricular region (2D model).
(Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: