Assessment of Pradosia huberi effects on the reproductive system of male rats.

Autor:	Cristina Silva Dos Santos E; Biotechnology Center, Federal University of Paraíba, 58051-970 João Pessoa, PB, Brazil lanafarma@gmail.com., Antunes PS; Biotechnology Center, Federal University of Paraíba, 58051-970 João Pessoa, PB, Brazil., Dos Santos FL; Biotechnology Center, Federal University of Paraíba, 58051-970 João Pessoa, PB, Brazil., Rocha Ade O; Biotechnology Center, Federal University of Paraíba, 58051-970 João Pessoa, PB, Brazil., Pita JC; Biotechnology Center, Federal University of Paraíba, 58051-970 João Pessoa, PB, Brazil., Xavier AL; Biotechnology Center, Federal University of Paraíba, 58051-970 João Pessoa, PB, Brazil., Macêdo CL; Biotechnology Center, Federal University of Paraíba, 58051-970 João Pessoa, PB, Brazil., Jacob KC; Biotechnology Center, Federal University of Paraíba, 58051-970 João Pessoa, PB, Brazil., de Oliveira NA; Biotechnology Center, Federal University of Paraíba, 58051-970 João Pessoa, PB, Brazil., de Medeiros AA; Institute of Scientific and Technological Research of Amapa, 68900-260 Macapá, AP, Brazil., Diniz Mde F; Department of Pharmaceutical Sciences, Federal University of Paraíba, 58051-970 João Pessoa, PB, Brazil., de Cássia da Silveira E Sá R; Department of Physiology and Pathology, Federal University of Paraíba, 58051-970 João Pessoa, PB, Brazil.
Jazyk:	angličtina
Zdroj:	Experimental biology and medicine (Maywood, N.J.) [Exp Biol Med (Maywood)] 2016 Mar; Vol. 241 (5), pp. 519-26. Date of Electronic Publication: 2016 Jan 07.
DOI:	10.1177/1535370215625133
Abstrakt:	Pradosia huberi is a species found in the Amazon region and used as an antiulcerogenic and gastroprotective agent; however, phytochemical analysis has revealed the presence of compounds with potential toxic effects on the reproductive system. For the evaluation of the toxicity of P. huberi on male fertility, male Wistar rats were divided into four groups: one control (distilled water p.o.) and three treated (hydroalcoholic extract of the stem bark of P. Huberi (PH-HAE) at doses of 1.22, 6.1, and 30.5 mg/kg p.o.) once daily, for 63 days. In the last week of treatment (from the 57th to the 63rd day), the rats were mated with untreated virgin females (n = 30/group) and were killed on day 64. To investigate the toxic potential of PH-HAE on the reproductive system of rats the following parameters were evaluated: sperm production, genotoxicity, and general development. The production of gametes and their morphology did not differ between control and treated groups. Treatment with PH-HAE did not result in fewer vaginal plugs formed, indicating that the ability to mate was not impaired, but caused an increase of 14.3 and 10.8% in the preimplantation loss index, a reduction of 14.3 and 10.8% in the implantation index, and a reduction of 5.6 and 8.2% in the postimplantation loss index of female rats mated with rats treated with 6.1 and 30.5 mg/kg, respectively, indicating a possible toxic action of PH-HAE on the reproductive system of rats. (© 2016 by the Society for Experimental Biology and Medicine.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu