| Autor: |
Sobhan PK; Present address: Sree Chitra Tirunal Institute for Medical Sciences and Technology, Biomedical Technology Wing, Thiruvananthapuram, Kerala, 695 012, India., Funa K; Sahlgrenska Cancer Center, Institute of Biomedicine, Sahlgrenska Academy at the University of Gothenburg, SE 40530, Gothenburg, Sweden. keiko.funa@gu.se. |
| Jazyk: |
angličtina |
| Zdroj: |
Molecular neurobiology [Mol Neurobiol] 2017 Jan; Vol. 54 (1), pp. 272-280. Date of Electronic Publication: 2016 Jan 06. |
| DOI: |
10.1007/s12035-015-9608-1 |
| Abstrakt: |
The orphan nuclear receptor TLX, also called NR2E1, is a factor important in the regulation of neural stem cell (NSC) self-renewal, neurogenesis, and maintenance. As a transcription factor, TLX is vital for the expression of genes implicated in neurogenesis, such as DNA replication, cell cycle, adhesion and migration. It acts by way of repressing or activating target genes, as well as controlling protein-protein interactions. Growing evidence suggests that dysregulated TLX acts in the initiation and progression of human disorders of the nervous system. This review describes recent knowledge about TLX expression, structure, targets, and biological functions, relevant to maintaining adult neural stem cells related to both neuropsychiatric conditions and certain nervous system tumours. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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