How to Create an Embryo Penetration Route.

Autor: Uchida H; Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan., Maruyama T; Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan., Masuda H; Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan., Uchida S; Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan., Miki F; Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan., Hihara H; Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan., Katakura S; Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan., Yoshimasa Y; Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan., Tanaka M; Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
Jazyk: angličtina
Zdroj: American journal of reproductive immunology (New York, N.Y. : 1989) [Am J Reprod Immunol] 2016 Mar; Vol. 75 (3), pp. 326-32. Date of Electronic Publication: 2016 Jan 05.
DOI: 10.1111/aji.12476
Abstrakt: Numerous past investigations into human implantation have tended to pay attention to the mechanism of embryo adhesion to endometrial cells or embryo invasion into endometrial stromal tissue. For successful pregnancy, however, embryo penetration through the endometrial epithelial cell (EEC) sheet is also absolutely required. To improve the performance of assisted reproductive technology, implantation studies should also focus on EEC dynamics, in particular, the action of EECs during embryo penetration. Although only EEC apoptosis has been proposed as a mechanism for the formation of the embryo penetration route, we have also recently reported that characteristic EEC collective motion, regulated by the epithelial to mesenchymal transition, also plays a key role in permitting embryo penetration. We review here how EECs form embryo penetration routes in light of our findings.
(© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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