Malignant Melanocytic Matricoma: A Report of 2 Cases and Review of the Literature.
| Autor: | Ardakani NM; Department of Anatomical Pathology, PathWest Laboratory Medicine, QEII Medical Centre, Perth, Australia; †Histology Unit, Western Diagnostic Pathology, Perth, Australia; and ‡School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia., Palmer DL, Wood BA |
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| Jazyk: | angličtina |
| Zdroj: | The American Journal of dermatopathology [Am J Dermatopathol] 2016 Jan; Vol. 38 (1), pp. 33-8. |
| DOI: | 10.1097/DAD.0000000000000329 |
| Abstrakt: | Background: To describe 2 cases of melanocytic matricoma with malignant histological features and systematically review previously reported cases of malignant melanocytic matricoma. Methods: Two cases of malignant melanocytic matricoma were identified from the practice of the authors. Additional 3 cases were identified in the literature. The clinical and pathological features of these 5 cases are described. Results: Malignant melanocytic matricoma occurs predominantly in sun-damaged skin of elderly individuals. The tumor is composed of atypical epithelial cells with brisk mitotic activity showing evidence of matrical keratinization and widespread positivity with beta-catenin. There is an admixed cytologically bland dendritic melanocytic component. To date, local recurrence has occurred in one case, but no cases of disseminated disease or death have been reported. Conclusions: Recognition of this rare tumor and separation from a range of diagnostic mimics is important to ensure adequate treatment by local excision and to allow further cases to be identified to better define the biological potential of this lesion. |
| Databáze: | MEDLINE |
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