The Prodrug Approach: A Successful Tool for Improving Drug Solubility.

Autor: Jornada DH; Faculdade de Ciências Farmacêuticas, UNESP-University Estadual Paulista, Rodovia Araraquara Jaú Km 01, 14801-902 Araraquara, São Paulo, Brasil. daniela.dhj@gmail.com., dos Santos Fernandes GF; Faculdade de Ciências Farmacêuticas, UNESP-University Estadual Paulista, Rodovia Araraquara Jaú Km 01, 14801-902 Araraquara, São Paulo, Brasil. guilhermefelipe@outlook.com., Chiba DE; Faculdade de Ciências Farmacêuticas, UNESP-University Estadual Paulista, Rodovia Araraquara Jaú Km 01, 14801-902 Araraquara, São Paulo, Brasil. chiba.diego@gmail.com., de Melo TR; Faculdade de Ciências Farmacêuticas, UNESP-University Estadual Paulista, Rodovia Araraquara Jaú Km 01, 14801-902 Araraquara, São Paulo, Brasil. trfmelo@gmail.com., dos Santos JL; Faculdade de Ciências Farmacêuticas, UNESP-University Estadual Paulista, Rodovia Araraquara Jaú Km 01, 14801-902 Araraquara, São Paulo, Brasil. santosjl@fcfar.unesp.br., Chung MC; Faculdade de Ciências Farmacêuticas, UNESP-University Estadual Paulista, Rodovia Araraquara Jaú Km 01, 14801-902 Araraquara, São Paulo, Brasil. chungmc@fcfar.unesp.br.
Jazyk: angličtina
Zdroj: Molecules (Basel, Switzerland) [Molecules] 2015 Dec 29; Vol. 21 (1), pp. 42. Date of Electronic Publication: 2015 Dec 29.
DOI: 10.3390/molecules21010042
Abstrakt: Prodrug design is a widely known molecular modification strategy that aims to optimize the physicochemical and pharmacological properties of drugs to improve their solubility and pharmacokinetic features and decrease their toxicity. A lack of solubility is one of the main obstacles to drug development. This review aims to describe recent advances in the improvement of solubility via the prodrug approach. The main chemical carriers and examples of successful strategies will be discussed, highlighting the advances of this field in the last ten years.
Databáze: MEDLINE
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