| Autor: |
Johnson OO; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago , Chicago, Illinois 60612, United States.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Lagos , CMUL Campus, Lagos 100254, Nigeria., Zhao M; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago , Chicago, Illinois 60612, United States., Gunn J; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago , Chicago, Illinois 60612, United States., Santarsiero BD; Center for Pharmaceutical Biotechnology and Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago , Chicago, Illinois 60607, United States., Yin ZQ; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago , Chicago, Illinois 60612, United States.; Department of Natural Medicinal Chemistry & State Key Laboratory of Natural Medicines, China Pharmaceutical University , Nanjing 210009, People's Republic of China., Ayoola GA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Lagos , CMUL Campus, Lagos 100254, Nigeria., Coker HA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Lagos , CMUL Campus, Lagos 100254, Nigeria., Che CT; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago , Chicago, Illinois 60612, United States. |
| Abstrakt: |
Four new prenylated anthranols, harunganols C-F (1-4), along with kenganthranol A (5), harunganin (6), and ferruginin A (7), were identified from the leaves of Harungana madagascariensis. The structures of compounds 2, 5, and 7 were confirmed by single-crystal X-ray diffraction analysis. Compound 1 is a unique symmetrical anthranol dimer connected via a CH2 group. Compound 4 possesses a unique C-10 hemiketal group. All anthranols were evaluated for their α-glucosidase inhibitory activities. They displayed a higher potency compared to acarbose except for 3 and 4. In particular, harunganol C (1) showed an IC50 value of 1.2 μM. |
